Gastrointestinal metabolic surgery for the treatment of type 2 diabetes mellitus

Medical therapy for type 2 diabetes mellitus is ineffective in the long term due to the progressive nature of the disease, which requires increasing medication doses and polypharmacy. Conversely, bariatric surgery has emerged as a cost-effective strategy for obese diabetic individuals; it has low co...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-10, Vol.20 (39), p.14315-14328
Main Authors: Pok, Eng-Hong, Lee, Wei-Jei
Format: Article
Language:English
Subjects:
Animals
Bariatric Surgery - adverse effects
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - surgery
Energy Metabolism
Gastrointestinal
Homeostasis
Humans
Metabolic
Obesity - blood
Obesity - complications
Obesity - diagnosis
Obesity - surgery
Patient Selection
Remission Induction
Risk Factors
surgery
Topic Highlight
Treatment Outcome
Type-2
Weight Loss
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Summary:Medical therapy for type 2 diabetes mellitus is ineffective in the long term due to the progressive nature of the disease, which requires increasing medication doses and polypharmacy. Conversely, bariatric surgery has emerged as a cost-effective strategy for obese diabetic individuals; it has low complication rates and results in durable weight loss, glycemic control and improvements in the quality of life, obesity-related co-morbidity and overall survival. The finding that glucose homeostasis can be achieved with a weight loss-independent mechanism immediately after bariatric surgery, especially gastric bypass, has led to the paradigm of metabolic surgery. However, the primary focus of metabolic surgery is the alteration of the physio-anatomy of the gastrointestinal tract to achieve glycemic control, metabolic control and cardio-metabolic risk reduction. To date, metabolic surgery is still not well defined, as it is used most frequently for less obese patients with poorly controlled diabetes. The mechanism of glycemic control is still incompletely understood. Published research findings on metabolic surgery are promising, but many aspects still need to be defined. This paper examines the proposed mechanism of diabetes remission, the efficacy of different types of metabolic procedures, the durability of glucose control, and the risks and complications associated with this procedure. We propose a tailored approach for the selection of the ideal metabolic procedure for different groups of patients, considering the indications and prognostic factors for diabetes remission.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i39.14315