MORIN, A FLAVONOID, ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN EXPERIMENTAL MYOCARDIAL ISCHEMIC RATS

Background: Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the pathology of myocardial infarction. Objective: The present study was designed to investigate the antioxidant potential of morin, a flavonoid in isoproterenol (ISO)-indu...

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Published in:African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-01, Vol.11 (3), p.14-20
Main Authors: Al-Numair, Khalid S, Chandramohan, Govindasamy, Alsaif, Mohammed A, Veeramani, Chinnadurai, El Newehy, Ahmed S
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - metabolism
Disease Models, Animal
Flavonoids - administration & dosage
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Humans
Isoproterenol
Lipid peroxidation
Lipid Peroxidation - drug effects
Male
Morin
Myocardial infarction
Myocardial Infarction - drug therapy
Myocardial Infarction - enzymology
Myocardial Infarction - metabolism
Rats
Rats, Wistar
Research Papers
Superoxide Dismutase - metabolism
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Summary:Background: Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the pathology of myocardial infarction. Objective: The present study was designed to investigate the antioxidant potential of morin, a flavonoid in isoproterenol (ISO)-induced myocardial infarction (MI), in rats. Materials and Methods: Male albino Wistar rats were pre-treated with morin (40 mg/kg), daily for a period of 30 days. After the treatment period, ISO (85 mg/kg), was subcutaneously injected in rats at an interval of 24 h for 2 days. Results: ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide (LOOH), in plasma and heart. Pretreatment with morin, the above changes were significantly reduced to near normal level. ISOadministered rats showed decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in heart. In addition, decrease the levels non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E in plasma and heart while ceruloplasmin in plasma. Conclusion: Pretreatment with morin, reversed these above biochemical changes towards normalcy. These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity.
ISSN:0189-6016
2505-0044
0189-6016
DOI:10.4314/ajtcam.v11i3.3