HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS

• Published in: African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-01, Vol.11 (2), p.447-451
• Main Authors: Rahim, Muhammad Saleh, Taha, Ekhlass Muhi, Al-janabi, Muneef Saeb, Al-douri, Bushra Ismael, Simon, Kumar Das, Mazlan, Abd Gaffar
• Format: Article
• Language: English
• Subjects: Animals; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - prevention & control; Cymbopogon - chemistry; Cymbopogon citratus; Glutathione - metabolism; Histopathology; Humans; Hydrogen peroxide; Hydrogen Peroxide - adverse effects; Liver - drug effects; Liver - metabolism; Liver enzymes; Male; Malondialdehyde - metabolism; Oxidative Stress - drug effects; Plant Extracts - administration & dosage; Plant Leaves - chemistry; Protective Agents - administration & dosage; Rat; Rats; Rats, Sprague-Dawley; Research Papers; Serum proteins; Vitamin C
• ISSN: 0189-6016; 2505-0044; 0189-6016
• DOI: 10.4314/ajtcam.v11i2.31

Background: Cymbopogon Citratus (Poaceae) a tropical perennial herb plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. This study aimed at evaluating the protective effects of C. citratus aqueous extract against liver injury induced by hydrogen peroxide (H2O2), in male rats. Materials and Methods: Twenty-five rats were randomly divided into five different groups of five animals in each group; (1) Control. (2) Received H2O2 (0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus (100 mg·kg-1 b wt), vitamin C (250 mg·kg-1 b wt) respectively. (5), was given C. citratus alone. The treatments were administered for 30 days. Blood samples were collected and serum was used for biochemical assay including liver enzymes activities, total protein, total bilirubin and malonaldehyde, glutathione in serum and liver homogenates. Liver was excised and routinely processed for histological examinations. Results: C. citratus attenuated liver damage due to H2O2 administration as indicated by the significant reduction (p