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HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS
Background: Cymbopogon Citratus (Poaceae) a tropical perennial herb plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. This study aimed at evaluating the protective effects of C....
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| Published in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-01, Vol.11 (2), p.447-451 |
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| container_end_page | 451 |
| container_issue | 2 |
| container_start_page | 447 |
| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Rahim, Muhammad Saleh Taha, Ekhlass Muhi Al-janabi, Muneef Saeb Al-douri, Bushra Ismael Simon, Kumar Das Mazlan, Abd Gaffar |
| description | Background: Cymbopogon Citratus (Poaceae) a tropical perennial herb
plant that is widely cultivated to be eaten either fresh with food or
dried in tea or soft drink has been reported to possess a number of
medicinal and aromatic properties. This study aimed at evaluating the
protective effects of C. citratus aqueous extract against liver injury
induced by hydrogen peroxide (H2O2), in male rats. Materials and
Methods: Twenty-five rats were randomly divided into five different
groups of five animals in each group; (1) Control. (2) Received H2O2
(0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus
(100 mg·kg-1 b wt), vitamin C (250 mg·kg-1 b wt)
respectively. (5), was given C. citratus alone. The treatments were
administered for 30 days. Blood samples were collected and serum was
used for biochemical assay including liver enzymes activities, total
protein, total bilirubin and malonaldehyde, glutathione in serum and
liver homogenates. Liver was excised and routinely processed for
histological examinations. Results: C. citratus attenuated liver damage
due to H2O2 administration as indicated by the significant reduction
(p |
| doi_str_mv | 10.4314/ajtcam.v11i2.31 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4202655</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1629585310</sourcerecordid><originalsourceid>FETCH-LOGICAL-b391t-b887496215e986648073b16ef4a88437351f5e30fc7a5966682c2cf83a61a2c63</originalsourceid><addsrcrecordid>eNpVkc9v0zAYhi0EYmVw5oZ85JLOv-NckELqtkFdU9IErSfLMQ5kSpuRpJPgr59HtwokS6_1-fFjSy8A7zGaMorZlbkdrdlP7zFuyJTiF2BCOOIBQoy9BBOEZRQIhMUFeDMMtwhRiUn4GlwQzigXFE_An6XaxEW2ybNCJUX6TUE1n_sdzOYw2V1_zjbZIlvDJC3yuCi3MP5aqsynuvEDj8WLOF1vC7jczfJsodZwo_LsJp2pIF3PykTN4MpLc5iuv5T5zge8jlcKetn2LXhVm3Zw757yEpRzVSTLYJUt0iReBRWN8BhUUoYsEgRzF0khmEQhrbBwNTNSMhpSjmvuKKptaHgkhJDEEltLagQ2xAp6CT6dvHfHau--W3cYe9Pqu77Zm_637kyj_z85ND_1j-5eM4KI4NwLPj4J-u7X0Q2j3jeDdW1rDq47DhoLEnHJKUYevTqhtu-GoXf1-RmM9GNj-tSY_tuYptjf-PDv7878c0UemJ6Aquna5uDOhO0bo5-Ho_ULMyQEfQAz95r6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1629585310</pqid></control><display><type>article</type><title>HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS</title><source>PubMed Central</source><creator>Rahim, Muhammad Saleh ; Taha, Ekhlass Muhi ; Al-janabi, Muneef Saeb ; Al-douri, Bushra Ismael ; Simon, Kumar Das ; Mazlan, Abd Gaffar</creator><creatorcontrib>Rahim, Muhammad Saleh ; Taha, Ekhlass Muhi ; Al-janabi, Muneef Saeb ; Al-douri, Bushra Ismael ; Simon, Kumar Das ; Mazlan, Abd Gaffar</creatorcontrib><description>Background: Cymbopogon Citratus (Poaceae) a tropical perennial herb
plant that is widely cultivated to be eaten either fresh with food or
dried in tea or soft drink has been reported to possess a number of
medicinal and aromatic properties. This study aimed at evaluating the
protective effects of C. citratus aqueous extract against liver injury
induced by hydrogen peroxide (H2O2), in male rats. Materials and
Methods: Twenty-five rats were randomly divided into five different
groups of five animals in each group; (1) Control. (2) Received H2O2
(0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus
(100 mg·kg-1 b wt), vitamin C (250 mg·kg-1 b wt)
respectively. (5), was given C. citratus alone. The treatments were
administered for 30 days. Blood samples were collected and serum was
used for biochemical assay including liver enzymes activities, total
protein, total bilirubin and malonaldehyde, glutathione in serum and
liver homogenates. Liver was excised and routinely processed for
histological examinations. Results: C. citratus attenuated liver damage
due to H2O2 administration as indicated by the significant reduction
(p<0.05), in the elevated levels of ALT, AST, ALP, LDH, TB, and MDA
in serum and liver homogenates; increase in TP and GSH levels in serum
and liver homogenates; and improvement of liver histo-pathological
changes. These effects of the extract were similar to that of vitamin C
which used as antioxidant reference. Conclusion: C. citratus could
effectively ameliorate H2O2-induced oxidative stress and prevent liver
injury in male rats.</description><identifier>ISSN: 0189-6016</identifier><identifier>EISSN: 2505-0044</identifier><identifier>EISSN: 0189-6016</identifier><identifier>DOI: 10.4314/ajtcam.v11i2.31</identifier><identifier>PMID: 25435631</identifier><language>eng</language><publisher>Nigeria: African Ethnomedicines Network</publisher><subject>Animals ; Chemical and Drug Induced Liver Injury - drug therapy ; Chemical and Drug Induced Liver Injury - metabolism ; Chemical and Drug Induced Liver Injury - prevention & control ; Cymbopogon - chemistry ; Cymbopogon citratus ; Glutathione - metabolism ; Histopathology ; Humans ; Hydrogen peroxide ; Hydrogen Peroxide - adverse effects ; Liver - drug effects ; Liver - metabolism ; Liver enzymes ; Male ; Malondialdehyde - metabolism ; Oxidative Stress - drug effects ; Plant Extracts - administration & dosage ; Plant Leaves - chemistry ; Protective Agents - administration & dosage ; Rat ; Rats ; Rats, Sprague-Dawley ; Research Papers ; Serum proteins ; Vitamin C</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2014-01, Vol.11 (2), p.447-451</ispartof><rights>Copyright 2014 - African Journal of Traditional, Complementary and Alternative Medicines</rights><rights>Copyright © Afr. J. Traditional Complementary and Alternative Medicines 2014 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b391t-b887496215e986648073b16ef4a88437351f5e30fc7a5966682c2cf83a61a2c63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202655/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202655/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25435631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahim, Muhammad Saleh</creatorcontrib><creatorcontrib>Taha, Ekhlass Muhi</creatorcontrib><creatorcontrib>Al-janabi, Muneef Saeb</creatorcontrib><creatorcontrib>Al-douri, Bushra Ismael</creatorcontrib><creatorcontrib>Simon, Kumar Das</creatorcontrib><creatorcontrib>Mazlan, Abd Gaffar</creatorcontrib><title>HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS</title><title>African journal of traditional, complementary, and alternative medicines</title><addtitle>Afr J Tradit Complement Altern Med</addtitle><description>Background: Cymbopogon Citratus (Poaceae) a tropical perennial herb
plant that is widely cultivated to be eaten either fresh with food or
dried in tea or soft drink has been reported to possess a number of
medicinal and aromatic properties. This study aimed at evaluating the
protective effects of C. citratus aqueous extract against liver injury
induced by hydrogen peroxide (H2O2), in male rats. Materials and
Methods: Twenty-five rats were randomly divided into five different
groups of five animals in each group; (1) Control. (2) Received H2O2
(0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus
(100 mg·kg-1 b wt), vitamin C (250 mg·kg-1 b wt)
respectively. (5), was given C. citratus alone. The treatments were
administered for 30 days. Blood samples were collected and serum was
used for biochemical assay including liver enzymes activities, total
protein, total bilirubin and malonaldehyde, glutathione in serum and
liver homogenates. Liver was excised and routinely processed for
histological examinations. Results: C. citratus attenuated liver damage
due to H2O2 administration as indicated by the significant reduction
(p<0.05), in the elevated levels of ALT, AST, ALP, LDH, TB, and MDA
in serum and liver homogenates; increase in TP and GSH levels in serum
and liver homogenates; and improvement of liver histo-pathological
changes. These effects of the extract were similar to that of vitamin C
which used as antioxidant reference. Conclusion: C. citratus could
effectively ameliorate H2O2-induced oxidative stress and prevent liver
injury in male rats.</description><subject>Animals</subject><subject>Chemical and Drug Induced Liver Injury - drug therapy</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>Chemical and Drug Induced Liver Injury - prevention & control</subject><subject>Cymbopogon - chemistry</subject><subject>Cymbopogon citratus</subject><subject>Glutathione - metabolism</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - adverse effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver enzymes</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Leaves - chemistry</subject><subject>Protective Agents - administration & dosage</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Papers</subject><subject>Serum proteins</subject><subject>Vitamin C</subject><issn>0189-6016</issn><issn>2505-0044</issn><issn>0189-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVkc9v0zAYhi0EYmVw5oZ85JLOv-NckELqtkFdU9IErSfLMQ5kSpuRpJPgr59HtwokS6_1-fFjSy8A7zGaMorZlbkdrdlP7zFuyJTiF2BCOOIBQoy9BBOEZRQIhMUFeDMMtwhRiUn4GlwQzigXFE_An6XaxEW2ybNCJUX6TUE1n_sdzOYw2V1_zjbZIlvDJC3yuCi3MP5aqsynuvEDj8WLOF1vC7jczfJsodZwo_LsJp2pIF3PykTN4MpLc5iuv5T5zge8jlcKetn2LXhVm3Zw757yEpRzVSTLYJUt0iReBRWN8BhUUoYsEgRzF0khmEQhrbBwNTNSMhpSjmvuKKptaHgkhJDEEltLagQ2xAp6CT6dvHfHau--W3cYe9Pqu77Zm_637kyj_z85ND_1j-5eM4KI4NwLPj4J-u7X0Q2j3jeDdW1rDq47DhoLEnHJKUYevTqhtu-GoXf1-RmM9GNj-tSY_tuYptjf-PDv7878c0UemJ6Aquna5uDOhO0bo5-Ho_ULMyQEfQAz95r6</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Rahim, Muhammad Saleh</creator><creator>Taha, Ekhlass Muhi</creator><creator>Al-janabi, Muneef Saeb</creator><creator>Al-douri, Bushra Ismael</creator><creator>Simon, Kumar Das</creator><creator>Mazlan, Abd Gaffar</creator><general>African Ethnomedicines Network</general><general>African Networks on Ethnomedicines</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS</title><author>Rahim, Muhammad Saleh ; Taha, Ekhlass Muhi ; Al-janabi, Muneef Saeb ; Al-douri, Bushra Ismael ; Simon, Kumar Das ; Mazlan, Abd Gaffar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b391t-b887496215e986648073b16ef4a88437351f5e30fc7a5966682c2cf83a61a2c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Chemical and Drug Induced Liver Injury - drug therapy</topic><topic>Chemical and Drug Induced Liver Injury - metabolism</topic><topic>Chemical and Drug Induced Liver Injury - prevention & control</topic><topic>Cymbopogon - chemistry</topic><topic>Cymbopogon citratus</topic><topic>Glutathione - metabolism</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - adverse effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver enzymes</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Leaves - chemistry</topic><topic>Protective Agents - administration & dosage</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Research Papers</topic><topic>Serum proteins</topic><topic>Vitamin C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahim, Muhammad Saleh</creatorcontrib><creatorcontrib>Taha, Ekhlass Muhi</creatorcontrib><creatorcontrib>Al-janabi, Muneef Saeb</creatorcontrib><creatorcontrib>Al-douri, Bushra Ismael</creatorcontrib><creatorcontrib>Simon, Kumar Das</creatorcontrib><creatorcontrib>Mazlan, Abd Gaffar</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahim, Muhammad Saleh</au><au>Taha, Ekhlass Muhi</au><au>Al-janabi, Muneef Saeb</au><au>Al-douri, Bushra Ismael</au><au>Simon, Kumar Das</au><au>Mazlan, Abd Gaffar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><addtitle>Afr J Tradit Complement Altern Med</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>11</volume><issue>2</issue><spage>447</spage><epage>451</epage><pages>447-451</pages><issn>0189-6016</issn><eissn>2505-0044</eissn><eissn>0189-6016</eissn><abstract>Background: Cymbopogon Citratus (Poaceae) a tropical perennial herb
plant that is widely cultivated to be eaten either fresh with food or
dried in tea or soft drink has been reported to possess a number of
medicinal and aromatic properties. This study aimed at evaluating the
protective effects of C. citratus aqueous extract against liver injury
induced by hydrogen peroxide (H2O2), in male rats. Materials and
Methods: Twenty-five rats were randomly divided into five different
groups of five animals in each group; (1) Control. (2) Received H2O2
(0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus
(100 mg·kg-1 b wt), vitamin C (250 mg·kg-1 b wt)
respectively. (5), was given C. citratus alone. The treatments were
administered for 30 days. Blood samples were collected and serum was
used for biochemical assay including liver enzymes activities, total
protein, total bilirubin and malonaldehyde, glutathione in serum and
liver homogenates. Liver was excised and routinely processed for
histological examinations. Results: C. citratus attenuated liver damage
due to H2O2 administration as indicated by the significant reduction
(p<0.05), in the elevated levels of ALT, AST, ALP, LDH, TB, and MDA
in serum and liver homogenates; increase in TP and GSH levels in serum
and liver homogenates; and improvement of liver histo-pathological
changes. These effects of the extract were similar to that of vitamin C
which used as antioxidant reference. Conclusion: C. citratus could
effectively ameliorate H2O2-induced oxidative stress and prevent liver
injury in male rats.</abstract><cop>Nigeria</cop><pub>African Ethnomedicines Network</pub><pmid>25435631</pmid><doi>10.4314/ajtcam.v11i2.31</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0189-6016 |
| ispartof | African journal of traditional, complementary, and alternative medicines, 2014-01, Vol.11 (2), p.447-451 |
| issn | 0189-6016 2505-0044 0189-6016 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4202655 |
| source | PubMed Central |
| subjects | Animals Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Cymbopogon - chemistry Cymbopogon citratus Glutathione - metabolism Histopathology Humans Hydrogen peroxide Hydrogen Peroxide - adverse effects Liver - drug effects Liver - metabolism Liver enzymes Male Malondialdehyde - metabolism Oxidative Stress - drug effects Plant Extracts - administration & dosage Plant Leaves - chemistry Protective Agents - administration & dosage Rat Rats Rats, Sprague-Dawley Research Papers Serum proteins Vitamin C |
| title | HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS |
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