Clinicopathological features of an ascending colon mixed adenoneuroendocrine carcinoma with clinical serosal invasion

Mixed adenoneuroendocrine carcinoma (MANEC) is exceedingly rare with a poor outcome. In this article, we reported a MANEC in a 68-year-old woman with a symptom of abdominal pain and distension. MANEC derived from the ascending colon with highly aggressive behavior. The diagnosis and distinguish of M...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2014-01, Vol.7 (9), p.6395-6398
Main Authors: Liu, Xi-Jun, Feng, Jin-Shan, Xiang, Wen-Yu, Kong, Bin, Wang, Ling-Mei, Zeng, Jin-Cheng, Liang, Yan-Fang
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Aged
Biomarkers, Tumor - analysis
Biopsy
Carcinoma, Neuroendocrine - chemistry
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - surgery
Case Report
Colectomy
Colonic Neoplasms - chemistry
Colonic Neoplasms - pathology
Colonic Neoplasms - surgery
Female
Humans
Immunohistochemistry
Intestinal Mucosa - chemistry
Intestinal Mucosa - pathology
Neoplasm Invasiveness
Neoplasms, Complex and Mixed - chemistry
Neoplasms, Complex and Mixed - pathology
Neoplasms, Complex and Mixed - surgery
Treatment Outcome
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Summary:Mixed adenoneuroendocrine carcinoma (MANEC) is exceedingly rare with a poor outcome. In this article, we reported a MANEC in a 68-year-old woman with a symptom of abdominal pain and distension. MANEC derived from the ascending colon with highly aggressive behavior. The diagnosis and distinguish of MANEC must base on histological findings and immunohistochemical findings. In this case, microscopic observation showed tumor cells were arranged in conglobate and nested by fibrous tissue with a visible cell atypia and mitotic. NEC-like and exocrine glandular cells were also been seen in a single neoplasm. MANEC tissues were immunopositive for CK, CK20, P53, CK7, CDX-2, Ki-67 (70%+), E-cad, CD56, CEA, Syn, villin and CgA, and immunonegative for CA125, NSE, ER and PR. Here, the patient was treated by surgical operation and was followed-up near 3 months, no local recurrence and distant metastasis.
ISSN:1936-2625