Functional ultrasound imaging of intrinsic connectivity in the living rat brain with high spatiotemporal resolution

Long-range coherences in spontaneous brain activity reflect functional connectivity. Here we propose a novel, highly resolved connectivity mapping approach, using ultrafast functional ultrasound (fUS), which enables imaging of cerebral microvascular haemodynamics deep in the anaesthetized rodent bra...

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Bibliographic Details
Published in:Nature communications 2014-10, Vol.5 (1), p.5023-5023, Article 5023
Main Authors: Osmanski, Bruno-Félix, Pezet, Sophie, Ricobaraza, Ana, Lenkei, Zsolt, Tanter, Mickael
Format: Article
Language:English
Subjects:
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Alzheimer's disease
Animals
Bioengineering
Brain - physiology
Brain Mapping - methods
Brain research
Contrast Media - chemistry
Echoencephalography
Hemodynamics
Humanities and Social Sciences
Image Processing, Computer-Assisted
Imaging
Life Sciences
Magnetic Resonance Imaging
Male
multidisciplinary
Neurons and Cognition
Physiology
Rats
Rats, Sprague-Dawley
Science
Science (multidisciplinary)
Ultrasonic imaging
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Summary:Long-range coherences in spontaneous brain activity reflect functional connectivity. Here we propose a novel, highly resolved connectivity mapping approach, using ultrafast functional ultrasound (fUS), which enables imaging of cerebral microvascular haemodynamics deep in the anaesthetized rodent brain, through a large thinned-skull cranial window, with pixel dimensions of 100 μm × 100 μm in-plane. The millisecond-range temporal resolution allows unambiguous cancellation of low-frequency cardio-respiratory noise. Both seed-based and singular value decomposition analysis of spatial coherences in the low-frequency (
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms6023