Ambient UV, Personal Sun Exposure and Risk of Multiple Primary Melanomas

Objective Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma. Methods We identified and enrolled 2,023 people with a first primary mel...

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Bibliographic Details
Published in:Cancer causes & control 2007-04, Vol.18 (3), p.295-304
Main Authors: Kricker, Anne, Armstrong, Bruce K., Goumas, Chris, Litchfield, Melisa, Begg, Colin B., Hummer, Amanda J., Marrett, Loraine D., Theis, Beth, Millikan, Robert C., Thomas, Nancy, Culver, Hoda Anton, Gallagher, Richard P., Dwyer, Terence, Rebbeck, Timothy R., Kanetsky, Peter A., Busam, Klaus, From, Lynn, Mujumdar, Urvi, Zanetti, Roberto, Berwick, Marianne
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age groups
Arithmetic mean
Beaches
Cancer
Child
Childhood
Environmental Exposure
Female
Humans
Irradiance
Job titles
Male
Melanoma
Melanoma - etiology
Middle Aged
Neoplasms, Multiple Primary - etiology
Neoplasms, Radiation-Induced
Occupational Exposure
Odds Ratio
Predisposing factors
Questionnaires
Radiation Dosage
Recreation
Risk Factors
Risk Reduction Behavior
Skin Neoplasms - etiology
Sun
Sunburn
Sunburn & sun tanning
Sunlight
Sunlight - adverse effects
Ultraviolet Rays - adverse effects
Vacations
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Summary:Objective Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma. Methods We identified and enrolled 2,023 people with a first primary melanoma (controls) and 1,125 with multiple primary melanomas (cases) in seven centers in four countries, recorded their residential history to assign ambient UV and interviewed them about their sun exposure. Results Risk of multiple primary melanomas increased significantly (P < 0.05) to OR = 2.10 for the highest exposure quarter of ambient UV irradiance at birth and 10 years of age, to OR = 1.38 for lifetime recreational sun exposure, to OR = 1.85 for beach and waterside activities, to OR = 1.57 for vacations in a sunnier climate, to OR = 1.50 for sunburns. Occupational sun exposure did not increase risk (OR = 1.03 for highest exposure). Recreational exposure at any age increased risk and appeared to add to risk from ambient UV in early life. Conclusions People who have had a melanoma can expect to reduce their risk of a further melanoma by reducing recreational sun exposure whatever their age. The same is probably true for a person who has never had a melanoma.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-006-0091-x