Roles of tissue plasminogen activator and its inhibitor in proliferative diabetic retinopathy

AIMTo investigate the role of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in proliferative diabetic retinopathy (PDR) and to discuss the correlations among t-PA, PAI and vascular endothelial growth factor (VEGF) expressions. METHODSA total of 36 vitreous samples wer...

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Bibliographic Details
Published in:International journal of ophthalmology 2014-10, Vol.7 (5), p.764-767
Main Authors: Wu, Shu-Ling, Zhan, Dong-Mei, Xi, Shu-Hong, He, Xiang-Lian
Format: Article
Language:English
Subjects:
Basic Research
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Summary:AIMTo investigate the role of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in proliferative diabetic retinopathy (PDR) and to discuss the correlations among t-PA, PAI and vascular endothelial growth factor (VEGF) expressions. METHODSA total of 36 vitreous samples were collected from 36 patients with PDR (PDR group), and 17 vitreous samples from 17 patients with idiopathic macular hole were used as control. The concentrations of t-PA, PAI and VEGF in samples were determined by ELISA method. The correlations among t-PA, PAI and VEGF expressions were discussed. RESULTSThe concentrations of t-PA, PAI and VEGF in the PDR group were significantly higher than those in the control group (P
ISSN:2222-3959
2227-4898
DOI:10.3980/j.issn.2222-3959.2014.04