Kinase Drug Discovery – What’s Next in the Field?

• Published in: ACS chemical biology 2013-01, Vol.8 (1), p.96-104
• Main Authors: Cohen, Philip, Alessi, Dario R
• Format: Article
• Language: English
• Subjects: Drug Discovery - trends; Humans; Inflammation - drug therapy; Phosphotransferases - chemistry; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - therapeutic use; Small Molecule Libraries - chemistry; Small Molecule Libraries - therapeutic use
• ISSN: 1554-8929; 1554-8937
• DOI: 10.1021/cb300610s

Over the past 15 years protein kinases have become the pharmaceutical industry’s most important class of drug target in the field of cancer. Some 20 drugs that target kinases have been approved for clinical use over the past decade, and hundreds more are undergoing clinical trials. However, the recent approval of the first protein kinase inhibitors for the treatment of inflammatory diseases, coupled with an enhanced understanding of the signaling networks that control the immune system, suggests that there will be a surge of interest in this area over the next 10 years. In this connection, we discuss opportunities for targeting protein kinases in the MyD88 signaling network for the development of drugs to treat chronic inflammatory and autoimmune diseases. Activating mutations in protein kinases underlie many other diseases and conditions, and we also discuss why the protein kinases SPAK/OSR1 and LRRK2 have recently become interesting targets for the treatment of hypertension and Parkinson’s disease, respectively, and the progress that has been made in developing LRRK2 inhibitors. Finally we suggest that more focus on the identification of inhibitors of kinase activation, rather than kinase activity, may pay dividends in identifying exquisitely specific inhibitors of signal transduction cascades, and we also highlight “pseudo-kinases” as an attractive and unexplored area for drug development that merits much more attention in the years to come.