Association of hypertension status and cardiovascular risks with sympathovagal imbalance in first degree relatives of type 2 diabetics

Aims/Introduction As reports show cardiovascular (CV) risks in first‐degree relatives (FDR) of type 2 diabetics, and autonomic imbalance predisposing to CV risks, in the present study we have assessed the contribution of sympathovagal imbalance (SVI) to CV risks in these subjects. Materials and Meth...

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Bibliographic Details
Published in:Journal of diabetes investigation 2014-07, Vol.5 (4), p.449-455
Main Authors: Pal, Gopal Krushna, Adithan, Chandrasekaran, Dutta, Tarun Kumar, Pal, Pravati, Nanda, Nivedita, Lalitha, Venugopal, Syamsunder, Avupati Naga
Format: Article
Language:English
Subjects:
Adipose tissue
Age
Autonomic imbalance
Autonomic nervous system
Blood pressure
Body mass index
Cardiovascular risk
Diabetes
Diabetes mellitus
Exercise
First-degree relatives of type 2 diabetics
Health care
Heart rate
Hip
Homeostasis
Hypertension
Insulin resistance
Laboratories
Metabolism
Morbidity
Multiple regression analysis
Original
Parasympathetic nervous system
Studies
Vagus nerve
Young adults
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Summary:Aims/Introduction As reports show cardiovascular (CV) risks in first‐degree relatives (FDR) of type 2 diabetics, and autonomic imbalance predisposing to CV risks, in the present study we have assessed the contribution of sympathovagal imbalance (SVI) to CV risks in these subjects. Materials and Methods Body mass index (BMI), waist‐to‐hip ratio (WHR), basal heart rate (BHR), blood pressure (BP), rate pressure product (RPP), and spectral indices of heart rate variability (HRV) were reordered and analyzed in FDR of type 2 diabetics (study group, n = 293) and in subjects with no family history of diabetes (control group, n = 405). Results The ratio of low‐frequency (LF) to high‐frequency (HF) power of HRV (LF–HF), a sensitive marker of SVI, was significantly increased (P 
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.12166