The Common Single-Nucleotide Polymorphism rs2681472 Is Associated With Early-Onset Preeclampsia in Northern Han Chinese Women

Preeclampsia, characterized by hypertension and proteinuria, remains a leading cause of maternal morbidity and mortality. Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant. The purpose of th...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2014-11, Vol.21 (11), p.1423-1427
Main Authors: Wan, Ji-Peng, Wang, Hong, Li, Chang-Zhong, Zhao, Han, You, Li, Shi, Dong-Hong, Sun, Xiu-Hua, Lv, Hong, Wang, Fei, Wen, Ze-Qing, Wang, Xie-Tong, Chen, Zi-Jiang
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - genetics
Case-Control Studies
China - epidemiology
Embryology
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original
Original Article
Phenotype
Plasma Membrane Calcium-Transporting ATPases - genetics
Polymorphism, Single Nucleotide
Pre-Eclampsia - diagnosis
Pre-Eclampsia - ethnology
Pre-Eclampsia - genetics
Pregnancy
Reproductive Medicine
Risk Factors
Young Adult
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Summary:Preeclampsia, characterized by hypertension and proteinuria, remains a leading cause of maternal morbidity and mortality. Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant. The purpose of this study was to evaluate the association between preeclampsia and rs268172 in a Northern Han Chinese population. We genotyped 1218 unrelated Northern Han Chinese women, including 515 patients with preeclampsia and 703 healthy controls. No significant differences were detected in the allele frequencies between patients and controls (P = .23). When patients were divided into early-onset and late-onset preeclampsia according to gestational age of disease onset, the allele frequencies significantly differed between controls and patients with early-onset preeclampsia (P = .02). Genotype frequencies also were significantly different between controls and patients early-onset preeclampsia when data were analyzed under additive (P = .03) and dominant (P = .009) models. We replicated this association in an independent Northern Han Chinese population and observed a significant difference in the allele frequencies between patients with early-onset preeclampsia and controls (P = .011). We report that rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719114527354