Glycyrrhizae Radix Methanol Extract Attenuates Methamphetamine-Induced Locomotor Sensitization and Conditioned Place Preference

Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and...

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Published in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Lee, Bong Hyo, Yang, Chae Ha, Kim, Sang Chan, Zhao, RongJie, Zhou, FuBo, Cho, Il Je, Chang, Suchan, Jung, Ji Yun, Zhang, Jie, Yang, YuPeng, Kim, Young Woo, Zhao, ZhengLin, Zhao, JunChang
Format: Article
Language:English
Subjects:
Acids
Care and treatment
Cocaine
Complications and side effects
Conditioning
Dopamine
Drug abuse
FDA approval
Health aspects
Laboratory animals
Medicinal plants
Medicine
Medicine, Botanic
Medicine, Herbal
Methamphetamine
Methanol
Neurobiology
Neurosciences
Pharmacology
Pharmacology, Experimental
Place preference conditioning
Preferences
Psychopharmacology
Rats
Rodents
Withdrawal
γ-Aminobutyric acid B receptors
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Summary:Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and conditioned place preference (CPP). A cohort of rats was treated with METH (1 mg/kg/day) for 6 consecutive days, subjected to 6 days of withdrawal, and then challenged with the same dose of METH to induce locomotor sensitization; during the withdrawal period, the rats were administered MEGR (60 or 180 mg/kg/day). A separate cohort of rats was treated with either METH or saline every other day for 6 days in METH-paired or saline-paired chambers, respectively, to induce CPP. These rats were also administered MEGR (180 mg/kg) prior to every METH or CPP expression test. Pretreatment with MEGR (60 and 180 mg/kg/day) attenuated the expression of METH-induced locomotor sensitization dose-dependently, and 180 mg/kg MEGR significantly inhibited the development and expression of METH-induced CPP. Furthermore, administration of a selective GABAb receptor antagonist (SCH50911) prior to MEGR treatment effectively blocked the inhibitory effects of MEGR on locomotor sensitization, but not CPP. These results suggest that Glycyrrhizae Radix blocked repeated METH-induced behavioral changes via GABAb receptors.
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/152063