Radical CH Functionalization of Heteroarenes under Electrochemical Control

Electrochemical reactions are shown to be effective for the CH functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the C...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2014-10, Vol.53 (44), p.11868-11871
Main Authors: O'Brien, Alexander G., Maruyama, Akinobu, Inokuma, Yasuhide, Fujita, Makoto, Baran, Phil S., Blackmond, Donna G.
Format: Article
Language:English
Subjects:
Carbon - chemistry
CH activation
electrochemistry
heterocycles
Heterocyclic Compounds - chemistry
Hydrogen - chemistry
Monitoring
Peroxides
radical reactions
Radicals
reaction mechanisms
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Summary:Electrochemical reactions are shown to be effective for the CH functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the CH functionalization of a series of heterocycles of interest in medicinal chemistry. Electrochemical reactions are shown to be effective for the CH functionalization of a number of heterocyclic substrates that are recalcitrant to conventional peroxide radical initiation conditions and of interest in medicinal chemistry. Monitoring reaction progress under electrochemical conditions provides mechanistic insight into the CH functionalization process.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201407948