Does use of ‘non-trial’ cessation support help explain the lack of effect from offering NRT to quitline callers in a RCT?

• Published in: Tobacco control 2014-11, Vol.23 (6), p.524-525
• Main Authors: Docherty, Graeme, Lewis, Sarah, McEwen, Andy, Bauld, Linda, Coleman, Tim
• Format: Article
• Language: English
• Subjects: Cancer; Cancer research; Carbon monoxide; Epidemiology; Experimentation; Female; Funding; Health Services - statistics & numerical data; Hotlines; Humans; Male; Medical research; Nicotine; P values; Public health; Randomized controlled trials; Research Letter; Research letters; Research universities; Smoking cessation; Smoking Cessation - methods; Smoking Prevention; Tobacco; Tobacco Use Cessation Devices - statistics & numerical data; Vouchers
• ISSN: 0964-4563; 1468-3318
• DOI: 10.1136/tobaccocontrol-2013-051107

Table 1 Total N=2591 No NRT N=1296 NRT N=1295 Unadjusted OR (95% CI; p value) Adjusted OR* (95% CI; p value) Adjusted OR[dagger] (95% CI; p value) Outcomes at 6 months, n (%) Prolonged cessation (inc. questionnaire data) (primary outcome) 490 (18.9) 261 (20.1) 229 (17.7) 0.85 (0.70 to 1.04; p=0.11) 0.86 (0.70 to 1.06; p=0.16) 0.84 (0.66 to 1.07; p=0.17) Carbon monoxide validated prolonged cessation 207 (8.0) 122 (9.4) 85 (6.6) 0.67 (0.50 to 0.90; p=0.008) 0.65 (0.48 to 0.88; p=0.005) 0.63 (0.45 to 0.86; p=0.004) Self-reported cessation for >=7 days 531 (20.5) 283 (21.8) 248 (19.1) 0.85 (0.70 to 1.03; p=0.09) 0.85 (0.70 to 1.04; p=0.13) 0.85 (0.67 to 1.07; p=0.17) Carbon monoxide validated cessation for >=7 days 200 (7.7) 119 (9.2) 81 (6.2) 0.66 (0.49 to 0.88; p=0.006) 0.64 (0.47 to 0.87; p=0.004) 0.62 (0.45 to 0.86; p=0.004) Reported cessation for >=3 months 401 (15.5) 216 (16.6) 185 (14.3) 0.83 (0.67 to 1.03; p=0.09) 0.84 (0.67 to 1.05; p=0.14) 0.86 (0.66 to 1.10; p=0.23) Reports one or more quit attempts lasting >24 h[dagger] 594 (22.9) 289 (22.3) 305 (23.5) 1.07 (0.88 to 1.28; p=0.49) 1.05 (0.86 to 1.27; p=0.60) 1.15 (0.88 to 1.50; p=0.30) Median (IQR) no. quit attempts reported 2 (1-3) 2 (1-4) 2 (1-3) n/a n/a n/a Outcomes at 1 month, n (%) Prolonged cessation since quit date 1040 (40.1) 520 (40.1) 520 (40.1) 0.99 (0.85 to 1.16; p=0.93) 1.01 (0.86 to 1.19; p=0.88) 1.00 (0.80 to 1.26; p=0.96) Reported cessation for >=7 days 831 (32.0) 417 (32.2) 414 (32.0) 0.98 (0.83 to 1.16; p=0.85) 0.99 (0.84 to 1.18; p=0.97) 0.97 (0.77 to 1.22; p=0.80) *Adjusted for age, gender, educational level and heaviness of smoking index; 2397 cases included in adjusted analyses. [dagger]Additionally adjusted for all forms of non-trial support.