Role of dorsal vagal complex A2 noradrenergic neurons in hindbrain glucoprivic inhibition of the luteinizing hormone surge in the steroid-primed ovariectomized female rat: Effects of 5-thioglucose on A2 functional biomarker and AMPK activity

• Published in: Neuroscience 2014-06, Vol.269, p.199-214
• Main Authors: Ibrahim, B.A, Briski, K.P
• Format: Article
• Language: English
• Subjects: 5-thioglucose; A2 noradrenergic neurons; Adrenergic Agents - pharmacology; Adrenergic alpha-1 Receptor Agonists - pharmacology; Adrenergic Neurons - drug effects; Adrenergic Neurons - physiology; AMP-Activated Protein Kinases - metabolism; AMPK; Animals; Biological and medical sciences; Biomarkers - metabolism; Central Nervous System Agents - pharmacology; Estradiol - pharmacology; estrogen receptor; Female; Fundamental and applied biological sciences. Psychology; Glucose - analogs & derivatives; Glucose - pharmacology; gonadotropin-releasing hormone; Gonadotropin-Releasing Hormone - metabolism; Hormones - pharmacology; Luteinizing Hormone - metabolism; Methoxamine - pharmacology; Neurology; Neurons - drug effects; Neurons - physiology; Ovariectomy; Oxidopamine - pharmacology; Progesterone - pharmacology; Rats, Sprague-Dawley; Receptors, Adenosine A2 - metabolism; Rhombencephalon - drug effects; Rhombencephalon - physiology; Vertebrates: nervous system and sense organs
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.02.015

Highlights • Glucoprivic cues from the caudal hindbrain restrain the preovulatory LH surge. • Hindbrain glucoprivation altered Fos expression in A2, but not other catecholamine cell groups. • Intra-preoptic methoxamine reversed glucoprivic effects on GnRH neuron Fos labeling and LH release. • 5TG stimulated Fos, but inhibited DBH protein profiles in A2 cells. • Hindbrain glucoprivation modified GnRH neuron AMPK and pAMPK protein expression.