Loading…

Gastrointestinal system

The functions of the gastrointestinal (GI) tract include digestion, absorption, excretion, and protection. In this review, we focus on the electrical activity of the stomach and small intestine, which underlies the motility of these organs, and where the most detailed systems descriptions and comput...

Full description

Saved in:
Bibliographic Details
Published in:Wiley interdisciplinary reviews. Mechanisms of disease 2010-01, Vol.2 (1), p.65-79
Main Authors: Cheng, Leo K., O'Grady, Gregory, Du, Peng, Egbuji, John U., Windsor, John A., Pullan, Andrew J.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4709-3fba3f0e4cfab1545d31bd2503e0b56d689dd9e97ecd6c539f9bbd6dfc735bad3
cites cdi_FETCH-LOGICAL-c4709-3fba3f0e4cfab1545d31bd2503e0b56d689dd9e97ecd6c539f9bbd6dfc735bad3
container_end_page 79
container_issue 1
container_start_page 65
container_title Wiley interdisciplinary reviews. Mechanisms of disease
container_volume 2
creator Cheng, Leo K.
O'Grady, Gregory
Du, Peng
Egbuji, John U.
Windsor, John A.
Pullan, Andrew J.
description The functions of the gastrointestinal (GI) tract include digestion, absorption, excretion, and protection. In this review, we focus on the electrical activity of the stomach and small intestine, which underlies the motility of these organs, and where the most detailed systems descriptions and computational models have been based to date. Much of this discussion is also applicable to the rest of the GI tract. This review covers four major spatial scales: cell, tissue, organ, and torso, and discusses the methods of investigation and the challenges associated with each. We begin by describing the origin of the electrical activity in the interstitial cells of Cajal, and its spread to smooth muscle cells. The spread of electrical activity through the stomach and small intestine is then described, followed by the resultant electrical and magnetic activity that may be recorded on the body surface. A number of common and highly symptomatic GI conditions involve abnormal electrical and/or motor activity, which are often termed functional disorders. In the last section of this review we address approaches being used to characterize and diagnose abnormalities in the electrical activity and how these might be applied in the clinical setting. The understanding of electrophysiology and motility of the GI system remains a challenging field, and the review discusses how biophysically based mathematical models can help to bridge gaps in our current knowledge, through integration of otherwise separate concepts. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Physiology > Mammalian Physiology in Health and Disease
doi_str_mv 10.1002/wsbm.19
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4221587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2006984882</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4709-3fba3f0e4cfab1545d31bd2503e0b56d689dd9e97ecd6c539f9bbd6dfc735bad3</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMoWqt49CaCBw-ydbJJdjcXQYtWpSrUiuIlJJusbt2Pmmyt_fduba0f4GkG5uFh3hehLQwtDOAfjp3KW5gvoQbmhHsA7GF5vjPgdA2tOzcACBjlfBWt-RCRADBuoO2OdJUt06IyrkoLme26iatMvoFWEpk5szmfTXR3dtpvn3vdm85F-7jrxTQE7pFESZKAoXEiFWaUaYKV9hkQA4oFOoi41tzw0MQ6iBnhCVdKBzqJQ8KU1KSJjmbe4UjlRsemqKzMxNCmubQTUcpU_L4U6bN4Kt8E9X3MorAW7M8Ftnwd1SFEnrrYZJksTDlyImS0zs0Jrcm9P-SgHNk6shP-FIloFPnfvtiWzlmTLH7BIKZdi2nXoq62iXZ-vr7gvsqtgYMZME4zM_nPI-5vT64-dd6MTuv-3xe0tC8iCEnIxP11R0D_shv0HkH0yAfwrZgN</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2006984882</pqid></control><display><type>article</type><title>Gastrointestinal system</title><source>Wiley</source><creator>Cheng, Leo K. ; O'Grady, Gregory ; Du, Peng ; Egbuji, John U. ; Windsor, John A. ; Pullan, Andrew J.</creator><creatorcontrib>Cheng, Leo K. ; O'Grady, Gregory ; Du, Peng ; Egbuji, John U. ; Windsor, John A. ; Pullan, Andrew J.</creatorcontrib><description>The functions of the gastrointestinal (GI) tract include digestion, absorption, excretion, and protection. In this review, we focus on the electrical activity of the stomach and small intestine, which underlies the motility of these organs, and where the most detailed systems descriptions and computational models have been based to date. Much of this discussion is also applicable to the rest of the GI tract. This review covers four major spatial scales: cell, tissue, organ, and torso, and discusses the methods of investigation and the challenges associated with each. We begin by describing the origin of the electrical activity in the interstitial cells of Cajal, and its spread to smooth muscle cells. The spread of electrical activity through the stomach and small intestine is then described, followed by the resultant electrical and magnetic activity that may be recorded on the body surface. A number of common and highly symptomatic GI conditions involve abnormal electrical and/or motor activity, which are often termed functional disorders. In the last section of this review we address approaches being used to characterize and diagnose abnormalities in the electrical activity and how these might be applied in the clinical setting. The understanding of electrophysiology and motility of the GI system remains a challenging field, and the review discusses how biophysically based mathematical models can help to bridge gaps in our current knowledge, through integration of otherwise separate concepts. Copyright © 2009 John Wiley &amp; Sons, Inc. This article is categorized under: Physiology &gt; Mammalian Physiology in Health and Disease</description><identifier>ISSN: 1939-5094</identifier><identifier>EISSN: 1939-005X</identifier><identifier>EISSN: 2692-9368</identifier><identifier>DOI: 10.1002/wsbm.19</identifier><identifier>PMID: 20836011</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>Abnormalities ; Animals ; Computer applications ; Digestive system ; Electric bridges ; Electrophysiology ; Electrophysiology - methods ; Excretion ; Gastrointestinal Motility - physiology ; Gastrointestinal system ; Gastrointestinal tract ; Gastrointestinal Tract - cytology ; Gastrointestinal Tract - metabolism ; Gastrointestinal Tract - physiology ; Humans ; Interstitial cells ; Interstitial cells of Cajal ; Intestinal Mucosa - cytology ; Intestinal Mucosa - metabolism ; Intestinal Mucosa - physiology ; Mathematical models ; Models, Biological ; Motility ; Motor activity ; Muscle, Smooth - physiology ; Muscles ; Organs ; Physiology ; Reviews ; Serous Membrane - physiology ; Small intestine ; Smooth muscle ; Stomach ; Stomach - physiology ; Torso</subject><ispartof>Wiley interdisciplinary reviews. Mechanisms of disease, 2010-01, Vol.2 (1), p.65-79</ispartof><rights>Copyright © 2009 John Wiley &amp; Sons, Inc.</rights><rights>Copyright Wiley Subscription Services, Inc. Jan/Feb 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4709-3fba3f0e4cfab1545d31bd2503e0b56d689dd9e97ecd6c539f9bbd6dfc735bad3</citedby><cites>FETCH-LOGICAL-c4709-3fba3f0e4cfab1545d31bd2503e0b56d689dd9e97ecd6c539f9bbd6dfc735bad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20836011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Leo K.</creatorcontrib><creatorcontrib>O'Grady, Gregory</creatorcontrib><creatorcontrib>Du, Peng</creatorcontrib><creatorcontrib>Egbuji, John U.</creatorcontrib><creatorcontrib>Windsor, John A.</creatorcontrib><creatorcontrib>Pullan, Andrew J.</creatorcontrib><title>Gastrointestinal system</title><title>Wiley interdisciplinary reviews. Mechanisms of disease</title><addtitle>WIREs Syst Biol Med</addtitle><description>The functions of the gastrointestinal (GI) tract include digestion, absorption, excretion, and protection. In this review, we focus on the electrical activity of the stomach and small intestine, which underlies the motility of these organs, and where the most detailed systems descriptions and computational models have been based to date. Much of this discussion is also applicable to the rest of the GI tract. This review covers four major spatial scales: cell, tissue, organ, and torso, and discusses the methods of investigation and the challenges associated with each. We begin by describing the origin of the electrical activity in the interstitial cells of Cajal, and its spread to smooth muscle cells. The spread of electrical activity through the stomach and small intestine is then described, followed by the resultant electrical and magnetic activity that may be recorded on the body surface. A number of common and highly symptomatic GI conditions involve abnormal electrical and/or motor activity, which are often termed functional disorders. In the last section of this review we address approaches being used to characterize and diagnose abnormalities in the electrical activity and how these might be applied in the clinical setting. The understanding of electrophysiology and motility of the GI system remains a challenging field, and the review discusses how biophysically based mathematical models can help to bridge gaps in our current knowledge, through integration of otherwise separate concepts. Copyright © 2009 John Wiley &amp; Sons, Inc. This article is categorized under: Physiology &gt; Mammalian Physiology in Health and Disease</description><subject>Abnormalities</subject><subject>Animals</subject><subject>Computer applications</subject><subject>Digestive system</subject><subject>Electric bridges</subject><subject>Electrophysiology</subject><subject>Electrophysiology - methods</subject><subject>Excretion</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Gastrointestinal Tract - cytology</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Gastrointestinal Tract - physiology</subject><subject>Humans</subject><subject>Interstitial cells</subject><subject>Interstitial cells of Cajal</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal Mucosa - physiology</subject><subject>Mathematical models</subject><subject>Models, Biological</subject><subject>Motility</subject><subject>Motor activity</subject><subject>Muscle, Smooth - physiology</subject><subject>Muscles</subject><subject>Organs</subject><subject>Physiology</subject><subject>Reviews</subject><subject>Serous Membrane - physiology</subject><subject>Small intestine</subject><subject>Smooth muscle</subject><subject>Stomach</subject><subject>Stomach - physiology</subject><subject>Torso</subject><issn>1939-5094</issn><issn>1939-005X</issn><issn>2692-9368</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMoWqt49CaCBw-ydbJJdjcXQYtWpSrUiuIlJJusbt2Pmmyt_fduba0f4GkG5uFh3hehLQwtDOAfjp3KW5gvoQbmhHsA7GF5vjPgdA2tOzcACBjlfBWt-RCRADBuoO2OdJUt06IyrkoLme26iatMvoFWEpk5szmfTXR3dtpvn3vdm85F-7jrxTQE7pFESZKAoXEiFWaUaYKV9hkQA4oFOoi41tzw0MQ6iBnhCVdKBzqJQ8KU1KSJjmbe4UjlRsemqKzMxNCmubQTUcpU_L4U6bN4Kt8E9X3MorAW7M8Ftnwd1SFEnrrYZJksTDlyImS0zs0Jrcm9P-SgHNk6shP-FIloFPnfvtiWzlmTLH7BIKZdi2nXoq62iXZ-vr7gvsqtgYMZME4zM_nPI-5vT64-dd6MTuv-3xe0tC8iCEnIxP11R0D_shv0HkH0yAfwrZgN</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Cheng, Leo K.</creator><creator>O'Grady, Gregory</creator><creator>Du, Peng</creator><creator>Egbuji, John U.</creator><creator>Windsor, John A.</creator><creator>Pullan, Andrew J.</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201001</creationdate><title>Gastrointestinal system</title><author>Cheng, Leo K. ; O'Grady, Gregory ; Du, Peng ; Egbuji, John U. ; Windsor, John A. ; Pullan, Andrew J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4709-3fba3f0e4cfab1545d31bd2503e0b56d689dd9e97ecd6c539f9bbd6dfc735bad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abnormalities</topic><topic>Animals</topic><topic>Computer applications</topic><topic>Digestive system</topic><topic>Electric bridges</topic><topic>Electrophysiology</topic><topic>Electrophysiology - methods</topic><topic>Excretion</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Gastrointestinal system</topic><topic>Gastrointestinal tract</topic><topic>Gastrointestinal Tract - cytology</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Gastrointestinal Tract - physiology</topic><topic>Humans</topic><topic>Interstitial cells</topic><topic>Interstitial cells of Cajal</topic><topic>Intestinal Mucosa - cytology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal Mucosa - physiology</topic><topic>Mathematical models</topic><topic>Models, Biological</topic><topic>Motility</topic><topic>Motor activity</topic><topic>Muscle, Smooth - physiology</topic><topic>Muscles</topic><topic>Organs</topic><topic>Physiology</topic><topic>Reviews</topic><topic>Serous Membrane - physiology</topic><topic>Small intestine</topic><topic>Smooth muscle</topic><topic>Stomach</topic><topic>Stomach - physiology</topic><topic>Torso</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Leo K.</creatorcontrib><creatorcontrib>O'Grady, Gregory</creatorcontrib><creatorcontrib>Du, Peng</creatorcontrib><creatorcontrib>Egbuji, John U.</creatorcontrib><creatorcontrib>Windsor, John A.</creatorcontrib><creatorcontrib>Pullan, Andrew J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Wiley interdisciplinary reviews. Mechanisms of disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Leo K.</au><au>O'Grady, Gregory</au><au>Du, Peng</au><au>Egbuji, John U.</au><au>Windsor, John A.</au><au>Pullan, Andrew J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrointestinal system</atitle><jtitle>Wiley interdisciplinary reviews. Mechanisms of disease</jtitle><addtitle>WIREs Syst Biol Med</addtitle><date>2010-01</date><risdate>2010</risdate><volume>2</volume><issue>1</issue><spage>65</spage><epage>79</epage><pages>65-79</pages><issn>1939-5094</issn><eissn>1939-005X</eissn><eissn>2692-9368</eissn><abstract>The functions of the gastrointestinal (GI) tract include digestion, absorption, excretion, and protection. In this review, we focus on the electrical activity of the stomach and small intestine, which underlies the motility of these organs, and where the most detailed systems descriptions and computational models have been based to date. Much of this discussion is also applicable to the rest of the GI tract. This review covers four major spatial scales: cell, tissue, organ, and torso, and discusses the methods of investigation and the challenges associated with each. We begin by describing the origin of the electrical activity in the interstitial cells of Cajal, and its spread to smooth muscle cells. The spread of electrical activity through the stomach and small intestine is then described, followed by the resultant electrical and magnetic activity that may be recorded on the body surface. A number of common and highly symptomatic GI conditions involve abnormal electrical and/or motor activity, which are often termed functional disorders. In the last section of this review we address approaches being used to characterize and diagnose abnormalities in the electrical activity and how these might be applied in the clinical setting. The understanding of electrophysiology and motility of the GI system remains a challenging field, and the review discusses how biophysically based mathematical models can help to bridge gaps in our current knowledge, through integration of otherwise separate concepts. Copyright © 2009 John Wiley &amp; Sons, Inc. This article is categorized under: Physiology &gt; Mammalian Physiology in Health and Disease</abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>20836011</pmid><doi>10.1002/wsbm.19</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1939-5094
ispartof Wiley interdisciplinary reviews. Mechanisms of disease, 2010-01, Vol.2 (1), p.65-79
issn 1939-5094
1939-005X
2692-9368
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4221587
source Wiley
subjects Abnormalities
Animals
Computer applications
Digestive system
Electric bridges
Electrophysiology
Electrophysiology - methods
Excretion
Gastrointestinal Motility - physiology
Gastrointestinal system
Gastrointestinal tract
Gastrointestinal Tract - cytology
Gastrointestinal Tract - metabolism
Gastrointestinal Tract - physiology
Humans
Interstitial cells
Interstitial cells of Cajal
Intestinal Mucosa - cytology
Intestinal Mucosa - metabolism
Intestinal Mucosa - physiology
Mathematical models
Models, Biological
Motility
Motor activity
Muscle, Smooth - physiology
Muscles
Organs
Physiology
Reviews
Serous Membrane - physiology
Small intestine
Smooth muscle
Stomach
Stomach - physiology
Torso
title Gastrointestinal system
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T23%3A19%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastrointestinal%20system&rft.jtitle=Wiley%20interdisciplinary%20reviews.%20Mechanisms%20of%20disease&rft.au=Cheng,%20Leo%20K.&rft.date=2010-01&rft.volume=2&rft.issue=1&rft.spage=65&rft.epage=79&rft.pages=65-79&rft.issn=1939-5094&rft.eissn=1939-005X&rft_id=info:doi/10.1002/wsbm.19&rft_dat=%3Cproquest_pubme%3E2006984882%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4709-3fba3f0e4cfab1545d31bd2503e0b56d689dd9e97ecd6c539f9bbd6dfc735bad3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2006984882&rft_id=info:pmid/20836011&rfr_iscdi=true