Benign giant-cell tumor of the common bile duct:A case report

Primary giant-cell tumors rarely arise in the common bile duct.We herein report a case of primary giantcell tumor of the common bile duct.The patient was an 81-year-old male who was diagnosed with a welldefined 1.2-cm mass projecting into the lumen of the middle common bile duct.Excision of the gall...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-11, Vol.20 (41), p.15448-15453
Main Authors: Wang, Dan-Dan, Zheng, Ya-Min, Teng, Liang-Hong, Sun, Yan-Ni, Gao, Wei, Wang, Lei-Ming, Wang, Yue-Hua, Li, Fei, Lu, De-Hong
Format: Article
Language:English
Subjects:
Aged, 80 and over
Anastomosis, Roux-en-Y
Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
bile
Biomarkers, Tumor - analysis
Biopsy
Case Report
CD163
Cholangiopancreatography, Magnetic Resonance
Cholecystectomy
Common
Common Bile Duct Neoplasms - immunology
Common Bile Duct Neoplasms - pathology
Common Bile Duct Neoplasms - surgery
duct
Giant Cell Tumors - immunology
Giant Cell Tumors - pathology
Giant Cell Tumors - surgery
Giant-cell
Humans
Immunohistochemistry
Jejunostomy
Male
Receptors, Cell Surface - analysis
Surgical
Tomography, X-Ray Computed
Treatment Outcome
tumor
Tumor Burden
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Summary:Primary giant-cell tumors rarely arise in the common bile duct.We herein report a case of primary giantcell tumor of the common bile duct.The patient was an 81-year-old male who was diagnosed with a welldefined 1.2-cm mass projecting into the lumen of the middle common bile duct.Excision of the gallbladder and extrahepatic bile duct and a Roux-en-Y cholangiojejunostomy were performed.Histologically,the tumor had no association with carcinomas of epithelial origin and was similar to giant-cell tumors of the bone.The tumor consisted of a mixture of mononuclear and multinucleated osteoclast-like giant cells.The mononuclear cells showed no atypical features,and their nuclei were similar to those of the multinucleated giant cells.CD68 was expressed on the mononuclear and multinucleated osteoclast-like giant cells,whereas CD163 immunoreactivity was restricted to the mononuclear cells.Six months after the operation,the patient was still alive and had no recurrence.The interest of this case lies in the rarity of this entity,the difficulty of preoperative diagnosis,and this tumor’s possible confusion with other malignant tumors.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i41.15448