Long‐term fat redistribution in ARV‐naïve HIV+ patients initiating a non‐thymidine containing regimen in clinical practice

Introduction Lipodystrophy is still a matter of concern in HIV+ patients receiving ART. However, long‐term fat change in patients taking non‐thymidine regimens is not well known. Materials and Methods A prospective ongoing fat change assessment including clinical evaluation and dexa scans (Hologic Q...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the International AIDS Society 2014-11, Vol.17 (4 Suppl 3), p.19553-n/a
Main Authors: Ferrer, Elena, Navarro, Antonio, Curto, Jordi, Medina, Pilar, Rozas, Nerea, Barrera, Gladys, Saumoy, Maria, Manuel Tiraboschi, Juan, Gomez, Carmen, Podzamczer, Daniel
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adipose tissues
AIDS
AIDS patients
Antiretroviral drugs
Care and treatment
Case studies
Demographic aspects
Development and progression
Estudi de casos
HIV
HIV (Viruses)
HIV infection
Human immunodeficiency virus
Lipodystrophy
Malalts de sida
Risk factors
Sexually transmitted diseases
STD
Teixit adipós
VIH (Virus)
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Lipodystrophy is still a matter of concern in HIV+ patients receiving ART. However, long‐term fat change in patients taking non‐thymidine regimens is not well known. Materials and Methods A prospective ongoing fat change assessment including clinical evaluation and dexa scans (Hologic QDR 4500) is being conducted in all consecutive patients initiating ART from January 2008. Arm, leg, trunk and total fat as well as fat mass ratio (FMR=% trunk fat/% leg fat) were determined. Patients with data at baseline (BL), 12 and 36 m are included in this analysis. ITT and OT were performed. Multivariate general linear models were used to assess changes in fat measures. Results One hundred patients were included. 81% men, 42.9 years, 18% AIDS, CD4 218.5 (6‐756), viral load 5 log (2.9‐6.8), leg fat 4644g, trunk fat 6693g, FMR 0.94. Around 40 patients (40%) initiated a PIr (17 LPVr, 11 ATVr, 9 DRVr, 3 FPVr), 34 (34%) NVP and 21 (21%) EFV. About 83% received TDF/FTC and 10% ABC/3TC. Groups were comparable at BL except for a lower viral load in NVP patients (p=0.047) and lower c‐LDL in PI patients (p=0.043). After 36 m, no patient presented a clinically evident lipodystrophy. At 12 m, an overall significant increase was found from baseline in trunk, leg and FMR (median 759 g, 479.4 g and 0.03, respectively, p
ISSN:1758-2652
1758-2652
DOI:10.7448/IAS.17.4.19553