Prevalence of anal human papillomavirus infection and cytologic abnormalities among HIV‐infected and HIV‐uninfected men who have sex with men

• Published in: Journal of the International AIDS Society 2014-11, Vol.17 (4 Suppl 3), p.19662-n/a
• Main Authors: Latini, Alessandra, Gabriella Dona, Maria, Ronchetti, Livia, Giglio, Amalia, Moretto, Domenico, Colafigli, Manuela, Laquintana, Valentina, Frasca, Mirko, Zaccarelli, Mauro, Antinori, Andrea, Cristaudo, Antonio, Giuliani, Massimo
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; AIDS; Anal cancer; Anus; Cancer; Cellular biology; Colorectal cancer; Cytology; HIV; Human immunodeficiency virus; Human papillomavirus; Infections; Lesions; Sexually transmitted diseases; STD
• ISSN: 1758-2652; 1758-2652
• DOI: 10.7448/IAS.17.4.19662

Introduction Human papillomavirus (HPV) is responsible for 85% of anal cancers. Recently, anal cancer incidence has been increasing, particularly in men who have sex with men (MSM). Cytology may be a useful tool for the detection of anal precancerous lesions. We assessed the prevalence and determinants of anal HPV infection and cytologic abnormalities among HIV‐infected and ‐uninfected MSM. Materials and Methods MSM ≥18‐year‐old attending an STI clinic in Rome (Italy) were enrolled. Anal cytologic samples were collected in PreservCyt (Hologic) using a Dacron swab. The Linear Array HPV Genotyping Test (Roche Diagnostics) was used for the detection and genotyping of 37 mucosal HPV types. Liquid‐based cytological slides were obtained using a ThinPrep2000 processor (Hologic). The morphology of the anal pap‐test was classified following the Bethesda 2001 guidelines. Results We enrolled 180 HIV‐infected (median age 41 years, IQR 33–47) and 438 HIV‐uninfected MSM (median age 32 years, IQR: 27–39). Most of the individuals were Caucasian (92.2% and 97.0%, respectively). HPV prevalence, both overall (93.3% vs 72.4%, p