Natural compounds as next-generation herbicides

Herbicides with new modes of action (MOAs) are badly needed because of rapidly evolving resistance to commercial herbicides, for which a new MOA has not been introduced for more than 20 years. The biggest pest management challenge for organic agriculture is the lack of effective natural product herb...

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Bibliographic Details
Published in:Plant physiology (Bethesda) 2014-11, Vol.166 (3), p.1090-1105
Main Authors: Dayan, Franck E, Duke, Stephen O
Format: Article
Language:English
Subjects:
bioactive properties
Biological Products - pharmacology
Biosynthesis
Biosynthetic Pathways - drug effects
Cell membranes
Enzymes
Herbicide Resistance
Herbicides
Herbicides - pharmacology
mechanism of action
organic production
Pesticidal action
Pests
phytotoxins
Plant cells
Plant Weeds - drug effects
Plant Weeds - enzymology
Plants
Streptomyces
Toxins
Update on Natural Compounds as Herbicides
UPDATES - FOCUS ISSUE
Weed Control
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Summary:Herbicides with new modes of action (MOAs) are badly needed because of rapidly evolving resistance to commercial herbicides, for which a new MOA has not been introduced for more than 20 years. The biggest pest management challenge for organic agriculture is the lack of effective natural product herbicides. The structural diversity and evolved biological activity of natural phytotoxins offer opportunities for the development of both directly-used natural compounds and synthetic herbicides with new target sties based on the structure of natural phytotoxins. Natural phytotoxins are also a source of discovery of new herbicide targets that can be the focus of traditional herbicide discovery efforts. The many examples of strong natural phytotoxins with MOAs other than those used by commercial herbicides indicate that there are herbicide molecular targets to be added to the current repertoire of commercial herbicide MOAs.
ISSN:0032-0889
1532-2548
DOI:10.1104/pp.114.239061