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Natural compounds as next-generation herbicides

Herbicides with new modes of action (MOAs) are badly needed because of rapidly evolving resistance to commercial herbicides, for which a new MOA has not been introduced for more than 20 years. The biggest pest management challenge for organic agriculture is the lack of effective natural product herb...

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Published in:	Plant physiology (Bethesda) 2014-11, Vol.166 (3), p.1090-1105
Main Authors:	Dayan, Franck E, Duke, Stephen O
Format:	Article
Language:	English
Subjects:	bioactive properties Biological Products - pharmacology Biosynthesis Biosynthetic Pathways - drug effects Cell membranes Enzymes Herbicide Resistance Herbicides Herbicides - pharmacology mechanism of action organic production Pesticidal action Pests phytotoxins Plant cells Plant Weeds - drug effects Plant Weeds - enzymology Plants Streptomyces Toxins Update on Natural Compounds as Herbicides UPDATES - FOCUS ISSUE Weed Control
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creator	Dayan, Franck E Duke, Stephen O
description	Herbicides with new modes of action (MOAs) are badly needed because of rapidly evolving resistance to commercial herbicides, for which a new MOA has not been introduced for more than 20 years. The biggest pest management challenge for organic agriculture is the lack of effective natural product herbicides. The structural diversity and evolved biological activity of natural phytotoxins offer opportunities for the development of both directly-used natural compounds and synthetic herbicides with new target sties based on the structure of natural phytotoxins. Natural phytotoxins are also a source of discovery of new herbicide targets that can be the focus of traditional herbicide discovery efforts. The many examples of strong natural phytotoxins with MOAs other than those used by commercial herbicides indicate that there are herbicide molecular targets to be added to the current repertoire of commercial herbicide MOAs.
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source	JSTOR Archival Journals and Primary Sources Collection【Remote access available】; Oxford Journals Online
subjects	bioactive properties Biological Products - pharmacology Biosynthesis Biosynthetic Pathways - drug effects Cell membranes Enzymes Herbicide Resistance Herbicides Herbicides - pharmacology mechanism of action organic production Pesticidal action Pests phytotoxins Plant cells Plant Weeds - drug effects Plant Weeds - enzymology Plants Streptomyces Toxins Update on Natural Compounds as Herbicides UPDATES - FOCUS ISSUE Weed Control
title	Natural compounds as next-generation herbicides
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