Argon: systematic review on neuro- and organoprotective properties of an "inert" gas

Argon belongs to the group of noble gases, which are regarded as chemically inert. Astonishingly some of these gases exert biological properties and during the last decades more and more reports demonstrated neuroprotective and organoprotective effects. Recent studies predominately use in vivo or in...

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Bibliographic Details
Published in:International journal of molecular sciences 2014-10, Vol.15 (10), p.18175-18196
Main Authors: Höllig, Anke, Schug, Anita, Fahlenkamp, Astrid V, Rossaint, Rolf, Coburn, Mark
Format: Article
Language:English
Subjects:
Animals
Argon - pharmacology
Argon - therapeutic use
Brain - drug effects
Brain - pathology
Brain Injuries - drug therapy
Brain Injuries - pathology
Brain Ischemia - drug therapy
Brain Ischemia - pathology
Gases
Humans
Molecular biology
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Review
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Summary:Argon belongs to the group of noble gases, which are regarded as chemically inert. Astonishingly some of these gases exert biological properties and during the last decades more and more reports demonstrated neuroprotective and organoprotective effects. Recent studies predominately use in vivo or in vitro models for ischemic pathologies to investigate the effect of argon treatment. Promising data has been published concerning pathologies like cerebral ischemia, traumatic brain injury and hypoxic ischemic encephalopathy. However, models applied and administration of the therapeutic gas vary. Here we provide a systematic review to summarize the available data on argon's neuro- and organoprotective effects and discuss its possible mechanism of action. We aim to provide a summary to allow further studies with a more homogeneous setting to investigate possible clinical applications of argon.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms151018175