Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear...

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Bibliographic Details
Published in:The Journal of biological chemistry 2014-11, Vol.289 (46), p.31673-31681
Main Authors: Bagriantsev, Sviatoslav N., Gracheva, Elena O., Gallagher, Patrick G.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anemia, Hemolytic, Congenital - genetics
Animals
Electrophysiological Phenomena
Erythrocytes - cytology
Humans
Hydrops Fetalis - genetics
Ion Channels - chemistry
Ion Channels - physiology
Mice
Minireviews
Molecular Sequence Data
Mutation
Neurons, Afferent - metabolism
Osteoclasts - cytology
Phylogeny
Protein Structure, Tertiary
Sequence Homology, Amino Acid
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Summary:Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R114.612697