COS1: an Arabidopsis coronatine insensitive1 suppressor essential for regulation of jasmonate-mediated plant defense and senescence

The Arabidopsis thaliana CORONATINE INSENSITIVE1 (COI1) gene encodes an F-box protein to assemble SCFCOI1 complexes essential for response to jasmonates (JAs), which are a family of plant signaling molecules required for many essential functions, including plant defense and reproduction. To better u...

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Bibliographic Details
Published in:The Plant cell 2004-05, Vol.16 (5), p.1132-1142
Main Authors: Xiao, S, Dai, L, Liu, F, Wang, Z, Peng, W, Xie, D
Format: Article
Language:English
Subjects:
Aging
Amino Acid Sequence
amino acid sequences
Arabidopsis - growth & development
Arabidopsis - physiology
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Arabidopsis thaliana
Base Sequence
binding proteins
Botrytis cinerea
Cellular senescence
Cloning, Molecular
Complementary DNA
COS1 gene
defense mechanisms
disease resistance
DNA, Plant - chemistry
DNA, Plant - genetics
enzymes
exons
fungal diseases of plants
gene expression
Gene expression regulation
Genetic mutation
jasmonic acid
lumazine synthase
Molecular Sequence Data
mutants
nucleotide sequences
phenotype
Phenotypes
Plant cells
Plant growth
plant pathogenic fungi
Plants
Recombinant Proteins - metabolism
Restriction Mapping
RNA
Root growth
Seedlings
senescence
structural genes
Suppression, Genetic
suppressor genes
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Summary:The Arabidopsis thaliana CORONATINE INSENSITIVE1 (COI1) gene encodes an F-box protein to assemble SCFCOI1 complexes essential for response to jasmonates (JAs), which are a family of plant signaling molecules required for many essential functions, including plant defense and reproduction. To better understand the molecular basis of JA action, we screened for suppressors of coi1 and isolated a coi1 suppressor1 (cos1) mutant. The cos1 mutation restores the coi1-related phenotypes, including defects in JA sensitivity, senescence, and plant defense responses. The COS1 gene was cloned through a map-based approach and found to encode lumazine synthase, a key component in the riboflavin pathway that is essential for diverse yet critical cellular processes. We demonstrated a novel function for the riboflavin pathway that acts downstream of COI1 in the JA signaling pathway and is required for suppression of the COI1-mediated root growth, senescence, and plant defense.
ISSN:1040-4651
1532-298X
DOI:10.1105/tpc.020370