Plasma and erythrocyte membrane phospholipids and fatty acids in Italian general population and hemodialysis patients

Dyslipidemia and abnormal phospholipid metabolism are frequent in uremic patients and increase their risk of cardiovascular disease (CVD): ω-3 polyunsaturated fatty acids (PUFAs) may reduce this risk in the general population. In this study we compared the plasma and erythrocyte cell membrane compos...

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Published in:Lipids in health and disease 2014-03, Vol.13 (1), p.54-54, Article 54
Main Authors: Dessì, Mariarita, Noce, Annalisa, Bertucci, Pierfrancesco, Noce, Gianluca, Rizza, Stefano, De Stefano, Alessandro, Manca di Villahermosa, Simone, Bernardini, Sergio, De Lorenzo, Antonino, Di Daniele, Nicola
Format: Article
Language:English
Subjects:
Adult
Analysis
Antioxidants
Body mass index
Cardiovascular diseases
Cholesterol
Erythrocyte Membrane - metabolism
Fatty acids
Fatty Acids - blood
Fatty Acids - metabolism
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-3 - metabolism
Fatty Acids, Omega-6 - blood
Fatty Acids, Omega-6 - metabolism
Female
Humans
Male
Mass spectrometry
Phospholipids - blood
Phospholipids - metabolism
Plasma
Renal Dialysis
Studies
Triglycerides - blood
Triglycerides - metabolism
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Summary:Dyslipidemia and abnormal phospholipid metabolism are frequent in uremic patients and increase their risk of cardiovascular disease (CVD): ω-3 polyunsaturated fatty acids (PUFAs) may reduce this risk in the general population. In this study we compared the plasma and erythrocyte cell membrane composition of PUFAs in a group of Caucasian hemodialysis (HD) patients and in a control group of healthy subjects and evaluated the erythrocyte/cell membrane fatty acid ratio as a marker of the dietary intake of phospholipids. The relationship between ω-3 and ω-6 fatty acids and the possible differences in PUFAs concentrations were also investigated. After obtaining a fully informed consent, a total of ninety-nine HD patients and 160 non uremic control subjects from "Tor Vergata" University Hospital were enrolled into the study. None of them took antioxidant drugs or dietary supplements for at least 90 days prior to the observation. Blood samples were analysed by gas-chromatographic coupled to a mass spectrometric detector.The daily intake of total calories, proteins, lipids and carbohydrates is significantly lower in HD patients than in controls (p 
ISSN:1476-511X
1476-511X
DOI:10.1186/1476-511x-13-54