Left ventricular strain distribution in healthy dogs and in dogs with tachycardia-induced dilated cardiomyopathy

• Published in: Cardiovascular ultrasound 2013-12, Vol.11 (1), p.43-43, Article 43
• Main Authors: Kusunose, Kenya, Zhang, Youhua, Mazgalev, Todor N, Thomas, James D, Popović, Zoran B
• Format: Article
• Language: English
• Subjects: Anesthesia; Animals; Cardiomyopathy, Dilated - diagnostic imaging; Cardiomyopathy, Dilated - etiology; Cardiomyopathy, Dilated - physiopathology; Dogs; Echocardiography - methods; Elastic Modulus; Elasticity Imaging Techniques - methods; Female; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Male; Reference Values; Stress, Mechanical; Tachycardia, Ventricular - complications; Tachycardia, Ventricular - diagnostic imaging; Tachycardia, Ventricular - physiopathology; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - physiopathology
• ISSN: 1476-7120; 1476-7120
• DOI: 10.1186/1476-7120-11-43

Recently, left ventricular (LV) strain distribution pattern has been assessed in several cardiac disease states. Tachycardia-induced cardiomyopathy (TIC) is an animal model of non-ischemic cardiomyopathy well characterized in terms of global LV dysfunction but with poor understanding of regional variability in LV function. We hypothesized that TIC induces specific changes in LV strain distribution pattern. Twenty five adult mongrel conscious dogs were trained to lie down calmly for echocardiography. In seven selected dogs, we implanted pacing system for TIC induction under general anesthesia. We measured LV geometry and function, strains, and torsion before and after the development of TIC in awake non-sedated state. In 25 healthy dogs, all three types of normal strain significantly increased from base to apex (p