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Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population
Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population. We evalu...
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| Published in: | BMC cardiovascular disorders 2014-08, Vol.14 (1), p.105-105, Article 105 |
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| container_title | BMC cardiovascular disorders |
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| creator | Won, Ki-Bum Chang, Hyuk-Jae Sung, Jimin Shin, Sanghoon Cho, In-Jeong Shim, Chi-Young Hong, Geu-Ru Kim, Young Jin Choi, Byung-Wook Chung, Namsik |
| description | Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.
We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.
The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P 100 (OR 1.57) in the non-diabetic subjects (P |
| doi_str_mv | 10.1186/1471-2261-14-105 |
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We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.
The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.
MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.]]></description><identifier>ISSN: 1471-2261</identifier><identifier>EISSN: 1471-2261</identifier><identifier>DOI: 10.1186/1471-2261-14-105</identifier><identifier>PMID: 25138993</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Biomarkers - blood ; Cardiovascular disease ; Care and treatment ; Chi-Square Distribution ; Complications and side effects ; Coronary Angiography - methods ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary heart disease ; Coronary Vessels - diagnostic imaging ; Cross-Sectional Studies ; CT imaging ; Diabetes Mellitus - diagnosis ; Diabetes Mellitus - epidemiology ; Diagnosis ; Diagnostic imaging ; Female ; Heart attacks ; Humans ; Incidence ; Insulin ; Insulin resistance ; Lipoproteins, HDL - blood ; Logistic Models ; Male ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - diagnosis ; Metabolic Syndrome - epidemiology ; Middle Aged ; Multidetector Computed Tomography ; Multivariate Analysis ; Odds Ratio ; Patient outcomes ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prevalence ; Republic of Korea - epidemiology ; Risk Factors ; Severity of Illness Index ; Type 2 diabetes ; Vascular Calcification - diagnostic imaging ; Vascular Calcification - epidemiology</subject><ispartof>BMC cardiovascular disorders, 2014-08, Vol.14 (1), p.105-105, Article 105</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Won et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Won et al.; licensee BioMed Central Ltd. 2014 Won et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-66e5757555815aa93c3dbaf5f3190920819760cba9ab5ca7502b783ae6714c393</citedby><cites>FETCH-LOGICAL-c491t-66e5757555815aa93c3dbaf5f3190920819760cba9ab5ca7502b783ae6714c393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236521/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1558886785?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25138993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Won, Ki-Bum</creatorcontrib><creatorcontrib>Chang, Hyuk-Jae</creatorcontrib><creatorcontrib>Sung, Jimin</creatorcontrib><creatorcontrib>Shin, Sanghoon</creatorcontrib><creatorcontrib>Cho, In-Jeong</creatorcontrib><creatorcontrib>Shim, Chi-Young</creatorcontrib><creatorcontrib>Hong, Geu-Ru</creatorcontrib><creatorcontrib>Kim, Young Jin</creatorcontrib><creatorcontrib>Choi, Byung-Wook</creatorcontrib><creatorcontrib>Chung, Namsik</creatorcontrib><title>Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population</title><title>BMC cardiovascular disorders</title><addtitle>BMC Cardiovasc Disord</addtitle><description><![CDATA[Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.
We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.
The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.
MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.]]></description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Chi-Square Distribution</subject><subject>Complications and side effects</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Cross-Sectional Studies</subject><subject>CT imaging</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Incidence</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Lipoproteins, HDL - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - diagnosis</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Multidetector Computed Tomography</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Patient outcomes</subject><subject>Plaque, Atherosclerotic</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Type 2 diabetes</subject><subject>Vascular Calcification - diagnostic imaging</subject><subject>Vascular Calcification - epidemiology</subject><issn>1471-2261</issn><issn>1471-2261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptUk1v1TAQjBCIlsKdE7LEhUuKHT8n8QWpasuHqMQFztbG2bznKrGD7bTq7-OPdUPLo0VoD2uNZ8bj1RbFa8GPhWjr92LTiLKqalGKTSm4elIc7qGnD84HxYuULjkXTcv18-KgUkK2WsvD4teZGwaM6LODkUFKwTrILnjWYb5G9GzCDF0YnWXpxvcxTMjA98yGGDzEGwYxI7XeJYSEDK9gXCBjz65d3jELsXdgiT7Ny4rmMIVthHlHSksmvfNbAlneIZsjJvQWWRjIDygBJuY8A3p6mklJySz7GiKCZ3OYl_F31JfFswHGhK_u-1Hx4-P599PP5cW3T19OTy5Ku9Eil3WNqqFSqhUKQEsr-w4GNUihua54K3RTc9uBhk5ZaBSvuqaVgHUjNlZqeVR8uPOdl27C3tLQIoxmjm6iQZgAzjy-8W5ntuHKbCpZq0qQwbt7gxh-LpiymVyyOI7gMSzJCKV0TTzFifr2H-plWKKn762stm3rplV_WVsY0Tg_BHrXrqbmREmtGiGrNffxf1hUPU7OBo-DI_yRgN8JbAwpRRz2fxTcrItn1s0y62bRicA1yZuHs9kL_myavAVbL9ei</recordid><startdate>20140820</startdate><enddate>20140820</enddate><creator>Won, Ki-Bum</creator><creator>Chang, Hyuk-Jae</creator><creator>Sung, Jimin</creator><creator>Shin, Sanghoon</creator><creator>Cho, In-Jeong</creator><creator>Shim, Chi-Young</creator><creator>Hong, Geu-Ru</creator><creator>Kim, Young Jin</creator><creator>Choi, Byung-Wook</creator><creator>Chung, Namsik</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140820</creationdate><title>Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population</title><author>Won, Ki-Bum ; Chang, Hyuk-Jae ; Sung, Jimin ; Shin, Sanghoon ; Cho, In-Jeong ; Shim, Chi-Young ; Hong, Geu-Ru ; Kim, Young Jin ; Choi, Byung-Wook ; Chung, Namsik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-66e5757555815aa93c3dbaf5f3190920819760cba9ab5ca7502b783ae6714c393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Chi-Square Distribution</topic><topic>Complications and side effects</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Cross-Sectional Studies</topic><topic>CT imaging</topic><topic>Diabetes Mellitus - diagnosis</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diagnosis</topic><topic>Diagnostic imaging</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Incidence</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Lipoproteins, HDL - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - diagnosis</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Multidetector Computed Tomography</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Patient outcomes</topic><topic>Plaque, Atherosclerotic</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Type 2 diabetes</topic><topic>Vascular Calcification - diagnostic imaging</topic><topic>Vascular Calcification - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Won, Ki-Bum</creatorcontrib><creatorcontrib>Chang, Hyuk-Jae</creatorcontrib><creatorcontrib>Sung, Jimin</creatorcontrib><creatorcontrib>Shin, Sanghoon</creatorcontrib><creatorcontrib>Cho, In-Jeong</creatorcontrib><creatorcontrib>Shim, Chi-Young</creatorcontrib><creatorcontrib>Hong, Geu-Ru</creatorcontrib><creatorcontrib>Kim, Young Jin</creatorcontrib><creatorcontrib>Choi, Byung-Wook</creatorcontrib><creatorcontrib>Chung, Namsik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC cardiovascular disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Won, Ki-Bum</au><au>Chang, Hyuk-Jae</au><au>Sung, Jimin</au><au>Shin, Sanghoon</au><au>Cho, In-Jeong</au><au>Shim, Chi-Young</au><au>Hong, Geu-Ru</au><au>Kim, Young Jin</au><au>Choi, Byung-Wook</au><au>Chung, Namsik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population</atitle><jtitle>BMC cardiovascular disorders</jtitle><addtitle>BMC Cardiovasc Disord</addtitle><date>2014-08-20</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>105</spage><epage>105</epage><pages>105-105</pages><artnum>105</artnum><issn>1471-2261</issn><eissn>1471-2261</eissn><abstract><![CDATA[Metabolic syndrome (MetS) is associated with increased risks of diabetes and coronary artery disease (CAD). Despite the controversial inclusion of established diabetes in MetS, the association between MetS and CAD according to diabetes status has not been elucidated in the Asian population.
We evaluated the association between MetS and CAD using the parameters including any plaque, obstructive plaque, and coronary artery calcium score (CACS) >100 according to diabetes status in 2,869 symptomatic Korean subjects who underwent cardiac computed tomographic angiography.
The prevalence of MetS was significantly higher in the diabetic subjects than in the non-diabetic subjects (69% vs. 34%, P <0.001). The incidence of any plaque (64% vs. 43%, P <0.001), obstructive plaque (26% vs. 13%, P = 0.006), and CACS >100 (23% vs. 12%, P = 0.012) was significantly higher in diabetic subjects than in non-diabetic subjects. Among the MetS components, decreased high-density lipoprotein level was significantly associated with any plaque (odds ratio [OR] 1.35), obstructive plaque (OR 1.55), and CACS >100 (OR 1.57) in the non-diabetic subjects (P <0.01, respectively). However, none of the MetS components were associated with all the parameters in the diabetic subjects. Multivariate regression analysis revealed that MetS and the number of MetS components (MetSN) were independently associated with any plaque (MetS: OR 1.55, P <0.001; MetSN: OR 1.22, P <0.001), obstructive plaque (MetS: OR 1.52, P = 0.003; MetSN: OR 1.25, P <0.001), and CACS >100 (MetS: OR 1.46, P = 0.015; MetSN: OR 1.21, P = 0.004) only in the non-diabetic subjects, respectively.
MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects among the symptomatic Korean population.]]></abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25138993</pmid><doi>10.1186/1471-2261-14-105</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC cardiovascular disorders, 2014-08, Vol.14 (1), p.105-105, Article 105 |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Aged Biomarkers - blood Cardiovascular disease Care and treatment Chi-Square Distribution Complications and side effects Coronary Angiography - methods Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - epidemiology Coronary heart disease Coronary Vessels - diagnostic imaging Cross-Sectional Studies CT imaging Diabetes Mellitus - diagnosis Diabetes Mellitus - epidemiology Diagnosis Diagnostic imaging Female Heart attacks Humans Incidence Insulin Insulin resistance Lipoproteins, HDL - blood Logistic Models Male Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - diagnosis Metabolic Syndrome - epidemiology Middle Aged Multidetector Computed Tomography Multivariate Analysis Odds Ratio Patient outcomes Plaque, Atherosclerotic Predictive Value of Tests Prevalence Republic of Korea - epidemiology Risk Factors Severity of Illness Index Type 2 diabetes Vascular Calcification - diagnostic imaging Vascular Calcification - epidemiology |
| title | Differential association between metabolic syndrome and coronary artery disease evaluated with cardiac computed tomography according to the presence of diabetes in a symptomatic Korean population |
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