Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons – a scoping review

Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and...

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Bibliographic Details
Published in:Obesity reviews 2014-07, Vol.15 (7), p.578-586
Main Authors: Bliddal, H, Leeds, A. R, Christensen, R
Format: Article
Language:English
Subjects:
analgesia
complications
Diet, Reducing
Disease Progression
economics
etiology
exercise
Humans
Obesity
Obesity - complications
Obesity - physiopathology
Obesity - therapy
Obesity Comorbidity
osteoarthritis
Osteoarthritis - etiology
Osteoarthritis - physiopathology
Osteoarthritis - therapy
patients
physiopathology
Prevalence
Quality of Life
Risk Factors
therapy
treatment
Weight Loss
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Summary:Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health‐related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis.
ISSN:1467-7881
1467-789X
DOI:10.1111/obr.12173