Deoxyribonucleic acid polymorphism in the apolipoprotein A-1―C-III gene cluster: association with hypertriglyceridemia

A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism i...

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Bibliographic Details
Published in:The Journal of clinical investigation 1985-09, Vol.76 (3), p.1090-1095
Main Authors: REES, A, STOCKS, J, SHARPE, C. R, VELLA, M. A, SHOULDERS, C. C, KATZ, J, JOWETT, N. I, BARALLE, F. E, GALTON, D. J
Format: Article
Language:English
Subjects:
Adolescent
Apolipoprotein A-I
Apolipoprotein C-III
Apolipoproteins A - blood
Apolipoproteins A - genetics
Apolipoproteins C - blood
Apolipoproteins C - genetics
Biological and medical sciences
Child
China - ethnology
Deoxyribonucleases, Type II Site-Specific
Disorders of blood lipids. Hyperlipoproteinemia
DNA - genetics
DNA Restriction Enzymes - metabolism
European Continental Ancestry Group
Female
Genes
Genotype
Humans
Hyperlipoproteinemia Type IV - genetics
Isoelectric Focusing
Lipoproteins, HDL - blood
Male
Medical sciences
Metabolic diseases
Pedigree
Polymorphism, Genetic
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Summary:A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism is found in significantly increased prevalence (P less than 0.001) in Caucasian hypertriglyceridemic subjects compared with race-matched controls, and its distribution in normal individuals of differing racial origins is reported. Furthermore, no alteration of high density lipoprotein or apolipoprotein A-I and apolipoprotein C-III phenotypes was observed in individuals with or without the polymorphism.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI112062