Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy

We have studied major histocompatibility complex markers in randomly ascertained Caucasian patients with gluten-sensitive enteropathy and their families. The frequencies of extended haplotypes, defined as haplotypes of specific HLA-B, DR, BF, C2, C4A, and C4B allelic combinations, occurring more fre...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of clinical investigation 1987, Vol.79 (1), p.251-256
Main Authors: ALPER, C. A, FLEISCHNICK, E, ZUHEIR AWDEH, KATZ, A. J, YUNIS, E. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Celiac Disease - genetics
Complement System Proteins - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Gene Frequency
Haplotypes
HLA Antigens - genetics
HLA-DR Antigens - genetics
Humans
Lactoylglutathione Lyase - genetics
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Major Histocompatibility Complex
Medical sciences
Other diseases. Semiology
Polymorphism, Genetic
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have studied major histocompatibility complex markers in randomly ascertained Caucasian patients with gluten-sensitive enteropathy and their families. The frequencies of extended haplotypes, defined as haplotypes of specific HLA-B, DR, BF, C2, C4A, and C4B allelic combinations, occurring more frequently than expected, were compared on patient chromosomes, on normal chromosomes from the study families, and on chromosomes from normal families. Over half of patient chromosomes consisted almost entirely of two extended haplotypes [HLA-B8, DR3, SC01] and [HLA-B44, DR7, FC31] which, with nonextended HLA-DR7, accounted for the previously observed HLA markers of this disease: HLA-B8, DR3, and DR7. There was no increase in HLA-DR3 on nonextended haplotypes or in other extended haplotypes with HLA-DR3 or DR7. The distribution of homozygotes and heterozygotes for HLA-DR3 and DR7 was consistent with recessive inheritance of the major histocompatibility complex-linked susceptibility gene for gluten-sensitive enteropathy. On the other hand, by odds ratio analysis and from the sum of DR3 and DR7 homozygotes compared with DR3/DR7 heterozygotes, there was an increase in heterozygotes and a decrease in homozygotes suggesting the presence of modifying phenomena.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI112791