Susceptibility to multiple sclerosis associated with an immunoglobulin gamma 3 restriction fragment length polymorphism

Susceptibility to multiple sclerosis (MS) has been linked to the immunoglobulin G (Gm) markers as well as HLA-DR genes. We have used a genomic Ig gamma 1 probe which detects polymorphisms in the gamma 1, gamma 2, gamma 3 and pseudogamma genes to identify restriction fragment length polymorphisms ass...

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Bibliographic Details
Published in:The Journal of clinical investigation 1987, Vol.79 (1), p.309-313
Main Authors: GAISER, C. N, JOHNSON, M. J, DE LANGE, G, RASSENTI, L, CAVALLI-SFORZA, L. L, STEINMAN, L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Gene Frequency
Genetic Linkage
Humans
Immunoglobulin Allotypes - genetics
Immunoglobulin gamma-Chains - genetics
Immunoglobulin Heavy Chains - genetics
Medical sciences
Multiple Sclerosis - genetics
Multiple Sclerosis - immunology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Polymorphism, Restriction Fragment Length
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Summary:Susceptibility to multiple sclerosis (MS) has been linked to the immunoglobulin G (Gm) markers as well as HLA-DR genes. We have used a genomic Ig gamma 1 probe which detects polymorphisms in the gamma 1, gamma 2, gamma 3 and pseudogamma genes to identify restriction fragment length polymorphisms associated with MS. A negative association was found between a 5.9-kilobase (kb) Bst EII gamma 3 fragment and MS. Southern blot analysis of genomic DNA revealed the presence of this fragment in 84 of 140 (60.0%) controls, but in only 17 of 59 (28.8%) MS patients. The frequency of the fragment in 47 myasthenia gravis and 16 Graves' disease patients was similar to that in controls, 60.0 and 62.5%, respectively.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI112801