Diabetes in the bio-breeding/worcester rat: induction and acceleration by spleen cell-conditioned media

Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats....

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Bibliographic Details
Published in:The Journal of clinical investigation 1985-10, Vol.76 (4), p.1692-1694
Main Authors: HANDLER, E. S, MORDES, J. P, SEALS, J, KOEVARY, S, LIKE, A. A, NAKANO, K, ROSSINI, A. A
Format: Article
Language:English
Subjects:
Age Factors
Animals
Autoimmune Diseases - immunology
Autoimmune Diseases - physiopathology
Biological and medical sciences
Concanavalin A - pharmacology
Culture Media - toxicity
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Disease Susceptibility
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Immunization, Passive
Lymphocyte Transfusion
Male
Medical sciences
Rats
Rats, Inbred BB
Rats, Inbred BUF
Rats, Inbred Strains
Rats, Inbred WF
Spleen - secretion
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Summary:Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats. Unconditioned media containing mitogen had no activity. Conditioned media also induced diabetes in resistant W-line BB/W rats but not in Wistar Furth rats. A soluble factor may activate a BB lymphocyte population that promotes diabetes.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI112156