Simple Sequence Repeats in the National Longitudinal Study of Adolescent Health: An Ethnically Diverse Resource for Genetic Analysis of Health and Behavior

Simple sequence repeats (SSRs) are one of the earliest available forms of genetic variation available for analysis and have been utilized in studies of neurological, behavioral, and health phenotypes. Although findings from these studies have been suggestive, their interpretation has been complicate...

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Bibliographic Details
Published in:Behavior genetics 2014-09, Vol.44 (5), p.487-497
Main Authors: Haberstick, Brett C., Smolen, Andrew, Stetler, Gary L., Tabor, Joyce W., Roy, Taylor, Rick Casey, H., Pardo, Alicia, Roy, Forest, Ryals, Lauren A., Hewitt, Christina, Whitsel, Eric A., Halpern, Carolyn T., Killeya-Jones, Ley A., Lessem, Jeffrey M., Hewitt, John K., Harris, Kathleen Mullan
Format: Article
Language:English
Subjects:
Adolescent
Behavior
Behavioral Science and Psychology
Clinical Psychology
Consortia
Dopamine
Ethnic Groups - genetics
Female
Genes
Genetic Predisposition to Disease - genetics
Genetic Variation - genetics
Genomes
Genotype
Health Psychology
Humans
Interviews
Longitudinal Studies
Male
Maternal & child health
Minisatellite Repeats - genetics
Original Research
Polymorphism
Psychology
Public Health
Response rates
Teenagers
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Summary:Simple sequence repeats (SSRs) are one of the earliest available forms of genetic variation available for analysis and have been utilized in studies of neurological, behavioral, and health phenotypes. Although findings from these studies have been suggestive, their interpretation has been complicated by a variety of factors including, among others, limited power due to small sample sizes. The current report details the availability, diversity, and allele and genotype frequencies of six commonly examined SSRs in the ethnically diverse, population-based National Longitudinal Study of Adolescent Health. A total of 106,743 genotypes were generated across 15,140 participants that included four microsatellites and two di-nucleotide repeats in three dopamine genes ( DAT1 , DRD4 , DRD5 ), the serotonin transporter, and monoamine oxidase A. Allele and genotype frequencies showed a complex pattern and differed significantly between populations. For both di-nucleotide repeats we observed a greater allelic diversity than previously reported. The availability of these six SSRs in a large, ethnically diverse sample with extensive environmental measures assessed longitudinally offers a unique resource for researchers interested in health and behavior.
ISSN:0001-8244
1573-3297
DOI:10.1007/s10519-014-9662-x