Ki67 as a predictor of poor prognosis in patients with triple-negative breast cancer

The aim of the current study was to investigate the expression of the proliferation antigen, Ki67, in triple-negative breast cancer (TNBC) and its correlation with clinicopathological factors. The expression of Ki67 and other biological indicators in 24 cases of TNBC tissues and 178 cases of non-TNB...

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Bibliographic Details
Published in:Oncology letters 2015-01, Vol.9 (1), p.149-152
Main Authors: LI, HAITAO, HAN, XINGHUA, LIU, YINGXIN, LIU, GUODONG, DONG, GUOMIN
Format: Article
Language:English
Subjects:
Accounting
Age
Breast cancer
Cell cycle
Chemotherapy
estrogen receptor
Genetic aspects
human epidermal growth factor receptor 2
Ki67
Lymphatic system
Medical prognosis
Metastasis
Molecular biology
Oncology
Patients
progesterone receptor
Prognosis
Properties
Tumor antigens
Tumors
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Summary:The aim of the current study was to investigate the expression of the proliferation antigen, Ki67, in triple-negative breast cancer (TNBC) and its correlation with clinicopathological factors. The expression of Ki67 and other biological indicators in 24 cases of TNBC tissues and 178 cases of non-TNBC tissues were detected using immunohistochemistry. Their correlation with the clinicopathological factors were also analyzed using the χ2 test. The positive rate of Ki67 expression in TNBC tissues was 83.3%, exhibiting a statistically significant difference when compared with that in non-TNBC tissues (73.0%) (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2014.2618