Serum adiponectin relates to shortened overall survival in men with squamous cell esophageal cancer treated with preoperative concurrent chemoradiotherapy: a pilot study

The convergence of nutritional, genetic, and inflammatory factors plays a significant role in the pathophysiology of squamous cell esophageal cancer (SCEC). The parameters of inflammation, indices of nutritional status, and adipocyte-derived hormones such as leptin, adiponectin, and resistin have be...

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Bibliographic Details
Published in:Medical science monitor 2014-11, Vol.20, p.2351-2357
Main Authors: Zemanová, Milada, Staňková, Barbora, Ušiakova, Zuzana, Tvrzická, Eva, Pazdro, Alexandr, Petruželka, Luboš, Zeman, Miroslav
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
Aged
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - surgery
Carcinoma, Squamous Cell - therapy
Chemoradiotherapy
Clinical Research
Esophageal Neoplasms - blood
Esophageal Neoplasms - surgery
Esophageal Neoplasms - therapy
Esophageal Squamous Cell Carcinoma
Female
Humans
Middle Aged
Multivariate Analysis
Pilot Projects
Preoperative Care
Proportional Hazards Models
Survival Analysis
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Summary:The convergence of nutritional, genetic, and inflammatory factors plays a significant role in the pathophysiology of squamous cell esophageal cancer (SCEC). The parameters of inflammation, indices of nutritional status, and adipocyte-derived hormones such as leptin, adiponectin, and resistin have been shown to be prognostic factors in some gastrointestinal and pancreatic cancers. Forty-two patients with SCEC were subjected to a multimodal regimen of concurrent neoadjuvant chemoradiotherapy (CRT) followed by surgery. We retrospectively analyzed the impact of pretreatment values of serum leptin, adiponectin, resistin, soluble leptin receptor, C-reactive protein, TNF alpha, leukocytes, and indices of nutritional status (BMI, plasma total protein, albumin, cholesterol, and triacylglycerols) on overall survival (OS). Univariate analysis revealed significant a negative correlation between OS and serum adiponectin (p=0.027), and a positive relationship was found between serum albumin (p=0.002), cholesterol (p=0.049) level, and OS. In multivariate analysis, only the trend (p=0.086) for negative serum adiponectin association with the OS was observed. In men with SCEC treated by neoadjuvant concurrent CRT and esophagectomy, high pretreatment level of serum adiponectin was associated with shorter OS while the serum albumin and cholesterol were associated with longer OS.
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.891088