Serum prolidase activity and oxidant-antioxidant status in children with chronic hepatitis B virus infection

• Published in: Italian journal of pediatrics 2014-11, Vol.40 (1), p.95-95, Article 95
• Main Authors: Şen, Velat, Uluca, Ünal, Ece, Aydın, Kaplan, İbrahim, Bozkurt, Fatma, Aktar, Fesih, Bağlı, Sedat, Tekin, Recep
• Format: Article
• Language: English
• Subjects: Adolescent; Antigens; Antioxidants; Antioxidants - metabolism; Child; Child, Preschool; Collagen; Deoxyribonucleic acid; Dipeptidases - blood; DNA; Enzymes; Family medical history; Female; Free radicals; Hepatitis; Hepatitis B, Chronic - blood; Humans; Hypotheses; Infections; Liver cirrhosis; Liver diseases; Male; Metabolism; Methods; Oxidants - blood; Oxidative Stress; Pediatrics; Prospective Studies; Rheumatic diseases; Studies
• ISSN: 1824-7288; 1720-8424; 1824-7288
• DOI: 10.1186/s13052-014-0095-1

Chronic hepatitis B (CHB) is a global health problem that can result in serious complications associated with collagen degradation. Prolidase is a specific imidodipeptidase that plays an important role in the breakdown of collagen. The aim of this study was to investigate prolidase activity and oxidant-antioxidant status in children with CHB. This prospective case control study includes 38 patients with CHB, 31 patients with inactive hepatitis B (IHB), and 29 healthy matched control subjects. Serum prolidase enzyme activity (SPEA), total antioxidant capacity (TAC), total oxidative activity (TOA), and malondialdehyde (MDA) level were measured and oxidative stress index (OSI) was calculated for each group. Patients with CHB had significantly higher SPEA levels (207.82 ± 186.80 IU/L) than did the controls (58.6 ± 38.1 IU/L) and IHB patients (67.1 ± 39.9) (p