Combined effect of established BMI loci on obesity-related traits in an Algerian population sample

Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR...

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Published in:BMC genetics 2014-11, Vol.15 (1), p.128-128, Article 128
Main Authors: Badsi, Manel Nassima, Mediene-Benchekor, Sounnia, Ouhaibi-Djellouli, Hadjira, Lardjam-Hetraf, Sarah Aicha, Boulenouar, Houssam, Meroufel, Djabaria Naïma, Hermant, Xavier, Hamani-Medjaoui, Imane, Saidi-Mehtar, Nadhira, Amouyel, Philippe, Houti, Leila, Meirhaeghe, Aline, Goumidi, Louisa
Format: Article
Language:English
Subjects:
Algeria
Analysis
Body Mass Index
Care and treatment
Disease susceptibility
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Humans
Medical research
Metabolic disorders
Obesity
Obesity - genetics
Polymorphism, Single Nucleotide
Risk factors
Studies
Type 2 diabetes
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Summary:Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study. We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m2 (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004). Our data showed that a GPS comprising 29 BMI established loci developed from Europeans seems to be a valid score in a North African population. Our findings contribute to a better understanding of the genetic susceptibility to obesity in Algeria.
ISSN:1471-2156
1471-2156
DOI:10.1186/s12863-014-0128-1