Combined effect of established BMI loci on obesity-related traits in an Algerian population sample

Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR...

Full description

Saved in:
Bibliographic Details
Published in:BMC genetics 2014-11, Vol.15 (1), p.128-128, Article 128
Main Authors: Badsi, Manel Nassima, Mediene-Benchekor, Sounnia, Ouhaibi-Djellouli, Hadjira, Lardjam-Hetraf, Sarah Aicha, Boulenouar, Houssam, Meroufel, Djabaria Naïma, Hermant, Xavier, Hamani-Medjaoui, Imane, Saidi-Mehtar, Nadhira, Amouyel, Philippe, Houti, Leila, Meirhaeghe, Aline, Goumidi, Louisa
Format: Article
Language:English
Subjects:
Algeria
Analysis
Body Mass Index
Care and treatment
Disease susceptibility
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Humans
Medical research
Metabolic disorders
Obesity
Obesity - genetics
Polymorphism, Single Nucleotide
Risk factors
Studies
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-b656t-e8a04a18c0c52e517c26d8bdd610635fa1b7fd6254abe60a6ed17ae1575cd44a3
cites cdi_FETCH-LOGICAL-b656t-e8a04a18c0c52e517c26d8bdd610635fa1b7fd6254abe60a6ed17ae1575cd44a3
container_end_page 128
container_issue 1
container_start_page 128
container_title BMC genetics
container_volume 15
creator Badsi, Manel Nassima
Mediene-Benchekor, Sounnia
Ouhaibi-Djellouli, Hadjira
Lardjam-Hetraf, Sarah Aicha
Boulenouar, Houssam
Meroufel, Djabaria Naïma
Hermant, Xavier
Hamani-Medjaoui, Imane
Saidi-Mehtar, Nadhira
Amouyel, Philippe
Houti, Leila
Meirhaeghe, Aline
Goumidi, Louisa
description Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study. We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m2 (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004). Our data showed that a GPS comprising 29 BMI established loci developed from Europeans seems to be a valid score in a North African population. Our findings contribute to a better understanding of the genetic susceptibility to obesity in Algeria.
doi_str_mv 10.1186/s12863-014-0128-1
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4247883</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A539567774</galeid><sourcerecordid>A539567774</sourcerecordid><originalsourceid>FETCH-LOGICAL-b656t-e8a04a18c0c52e517c26d8bdd610635fa1b7fd6254abe60a6ed17ae1575cd44a3</originalsourceid><addsrcrecordid>eNqNkltrFTEQxxdRbK1-AF9kwRd92JrJbeOLcDzeDlQK3l5Dkp09TdlNtptdsd_eHE6tXalQQsgw85v_DDMpiqdAjgGUfJWAKskqAjxfqiq4VxwCr6GiIOT9G_ZB8Silc0KgVpQ_LA6o4JQSwQ4Lu4699QGbEtsW3VTGtsQ0Gdv5dJa9bz9vyi46X8ZQRovJT5fViJ2ZcmwajZ9S6UNpQrnqtjj6bAxxmHPc54Rk-qHDx8WD1nQJn1y9R8X3D--_rT9VJ6cfN-vVSWWlkFOFyhBuQDniBEUBtaOyUbZpJBDJRGvA1m0jc-vGoiRGYgO1QRC1cA3nhh0Vb_a6w2x7bByG3GCnh9H3ZrzU0Xi9jAR_prfxp-aU10qxLPBuL2B9_I_AMuJir_c70HkHercDDVnmxVUfY7yY8zB175PDrjMB45w0SEk5zfX4HVAmCBWMkow-_wc9j_MY8kAzRZUCDgz-UlvTofahjblRtxPVK8FeC1nX9a7s8S1UPg323sWArc_-RcLLRUJmJvw1bc2ckt58_XJ39vTHkoU968aY0ojt9bCB6N0Xv3W8z26u-Trjz59mvwG9DPSf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1628814131</pqid></control><display><type>article</type><title>Combined effect of established BMI loci on obesity-related traits in an Algerian population sample</title><source>PubMed Central</source><creator>Badsi, Manel Nassima ; Mediene-Benchekor, Sounnia ; Ouhaibi-Djellouli, Hadjira ; Lardjam-Hetraf, Sarah Aicha ; Boulenouar, Houssam ; Meroufel, Djabaria Naïma ; Hermant, Xavier ; Hamani-Medjaoui, Imane ; Saidi-Mehtar, Nadhira ; Amouyel, Philippe ; Houti, Leila ; Meirhaeghe, Aline ; Goumidi, Louisa</creator><creatorcontrib>Badsi, Manel Nassima ; Mediene-Benchekor, Sounnia ; Ouhaibi-Djellouli, Hadjira ; Lardjam-Hetraf, Sarah Aicha ; Boulenouar, Houssam ; Meroufel, Djabaria Naïma ; Hermant, Xavier ; Hamani-Medjaoui, Imane ; Saidi-Mehtar, Nadhira ; Amouyel, Philippe ; Houti, Leila ; Meirhaeghe, Aline ; Goumidi, Louisa</creatorcontrib><description>Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study. We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m2 (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004). Our data showed that a GPS comprising 29 BMI established loci developed from Europeans seems to be a valid score in a North African population. Our findings contribute to a better understanding of the genetic susceptibility to obesity in Algeria.</description><identifier>ISSN: 1471-2156</identifier><identifier>EISSN: 1471-2156</identifier><identifier>DOI: 10.1186/s12863-014-0128-1</identifier><identifier>PMID: 25422053</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Algeria ; Analysis ; Body Mass Index ; Care and treatment ; Disease susceptibility ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Humans ; Medical research ; Metabolic disorders ; Obesity ; Obesity - genetics ; Polymorphism, Single Nucleotide ; Risk factors ; Studies ; Type 2 diabetes</subject><ispartof>BMC genetics, 2014-11, Vol.15 (1), p.128-128, Article 128</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Badsi et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Badsi et al.; licensee BioMed Central Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b656t-e8a04a18c0c52e517c26d8bdd610635fa1b7fd6254abe60a6ed17ae1575cd44a3</citedby><cites>FETCH-LOGICAL-b656t-e8a04a18c0c52e517c26d8bdd610635fa1b7fd6254abe60a6ed17ae1575cd44a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247883/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247883/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25422053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Badsi, Manel Nassima</creatorcontrib><creatorcontrib>Mediene-Benchekor, Sounnia</creatorcontrib><creatorcontrib>Ouhaibi-Djellouli, Hadjira</creatorcontrib><creatorcontrib>Lardjam-Hetraf, Sarah Aicha</creatorcontrib><creatorcontrib>Boulenouar, Houssam</creatorcontrib><creatorcontrib>Meroufel, Djabaria Naïma</creatorcontrib><creatorcontrib>Hermant, Xavier</creatorcontrib><creatorcontrib>Hamani-Medjaoui, Imane</creatorcontrib><creatorcontrib>Saidi-Mehtar, Nadhira</creatorcontrib><creatorcontrib>Amouyel, Philippe</creatorcontrib><creatorcontrib>Houti, Leila</creatorcontrib><creatorcontrib>Meirhaeghe, Aline</creatorcontrib><creatorcontrib>Goumidi, Louisa</creatorcontrib><title>Combined effect of established BMI loci on obesity-related traits in an Algerian population sample</title><title>BMC genetics</title><addtitle>BMC Genet</addtitle><description>Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study. We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m2 (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004). Our data showed that a GPS comprising 29 BMI established loci developed from Europeans seems to be a valid score in a North African population. Our findings contribute to a better understanding of the genetic susceptibility to obesity in Algeria.</description><subject>Algeria</subject><subject>Analysis</subject><subject>Body Mass Index</subject><subject>Care and treatment</subject><subject>Disease susceptibility</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Medical research</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Type 2 diabetes</subject><issn>1471-2156</issn><issn>1471-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNkltrFTEQxxdRbK1-AF9kwRd92JrJbeOLcDzeDlQK3l5Dkp09TdlNtptdsd_eHE6tXalQQsgw85v_DDMpiqdAjgGUfJWAKskqAjxfqiq4VxwCr6GiIOT9G_ZB8Silc0KgVpQ_LA6o4JQSwQ4Lu4699QGbEtsW3VTGtsQ0Gdv5dJa9bz9vyi46X8ZQRovJT5fViJ2ZcmwajZ9S6UNpQrnqtjj6bAxxmHPc54Rk-qHDx8WD1nQJn1y9R8X3D--_rT9VJ6cfN-vVSWWlkFOFyhBuQDniBEUBtaOyUbZpJBDJRGvA1m0jc-vGoiRGYgO1QRC1cA3nhh0Vb_a6w2x7bByG3GCnh9H3ZrzU0Xi9jAR_prfxp-aU10qxLPBuL2B9_I_AMuJir_c70HkHercDDVnmxVUfY7yY8zB175PDrjMB45w0SEk5zfX4HVAmCBWMkow-_wc9j_MY8kAzRZUCDgz-UlvTofahjblRtxPVK8FeC1nX9a7s8S1UPg323sWArc_-RcLLRUJmJvw1bc2ckt58_XJ39vTHkoU968aY0ojt9bCB6N0Xv3W8z26u-Trjz59mvwG9DPSf</recordid><startdate>20141125</startdate><enddate>20141125</enddate><creator>Badsi, Manel Nassima</creator><creator>Mediene-Benchekor, Sounnia</creator><creator>Ouhaibi-Djellouli, Hadjira</creator><creator>Lardjam-Hetraf, Sarah Aicha</creator><creator>Boulenouar, Houssam</creator><creator>Meroufel, Djabaria Naïma</creator><creator>Hermant, Xavier</creator><creator>Hamani-Medjaoui, Imane</creator><creator>Saidi-Mehtar, Nadhira</creator><creator>Amouyel, Philippe</creator><creator>Houti, Leila</creator><creator>Meirhaeghe, Aline</creator><creator>Goumidi, Louisa</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141125</creationdate><title>Combined effect of established BMI loci on obesity-related traits in an Algerian population sample</title><author>Badsi, Manel Nassima ; Mediene-Benchekor, Sounnia ; Ouhaibi-Djellouli, Hadjira ; Lardjam-Hetraf, Sarah Aicha ; Boulenouar, Houssam ; Meroufel, Djabaria Naïma ; Hermant, Xavier ; Hamani-Medjaoui, Imane ; Saidi-Mehtar, Nadhira ; Amouyel, Philippe ; Houti, Leila ; Meirhaeghe, Aline ; Goumidi, Louisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b656t-e8a04a18c0c52e517c26d8bdd610635fa1b7fd6254abe60a6ed17ae1575cd44a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Algeria</topic><topic>Analysis</topic><topic>Body Mass Index</topic><topic>Care and treatment</topic><topic>Disease susceptibility</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Medical research</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Badsi, Manel Nassima</creatorcontrib><creatorcontrib>Mediene-Benchekor, Sounnia</creatorcontrib><creatorcontrib>Ouhaibi-Djellouli, Hadjira</creatorcontrib><creatorcontrib>Lardjam-Hetraf, Sarah Aicha</creatorcontrib><creatorcontrib>Boulenouar, Houssam</creatorcontrib><creatorcontrib>Meroufel, Djabaria Naïma</creatorcontrib><creatorcontrib>Hermant, Xavier</creatorcontrib><creatorcontrib>Hamani-Medjaoui, Imane</creatorcontrib><creatorcontrib>Saidi-Mehtar, Nadhira</creatorcontrib><creatorcontrib>Amouyel, Philippe</creatorcontrib><creatorcontrib>Houti, Leila</creatorcontrib><creatorcontrib>Meirhaeghe, Aline</creatorcontrib><creatorcontrib>Goumidi, Louisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Badsi, Manel Nassima</au><au>Mediene-Benchekor, Sounnia</au><au>Ouhaibi-Djellouli, Hadjira</au><au>Lardjam-Hetraf, Sarah Aicha</au><au>Boulenouar, Houssam</au><au>Meroufel, Djabaria Naïma</au><au>Hermant, Xavier</au><au>Hamani-Medjaoui, Imane</au><au>Saidi-Mehtar, Nadhira</au><au>Amouyel, Philippe</au><au>Houti, Leila</au><au>Meirhaeghe, Aline</au><au>Goumidi, Louisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined effect of established BMI loci on obesity-related traits in an Algerian population sample</atitle><jtitle>BMC genetics</jtitle><addtitle>BMC Genet</addtitle><date>2014-11-25</date><risdate>2014</risdate><volume>15</volume><issue>1</issue><spage>128</spage><epage>128</epage><pages>128-128</pages><artnum>128</artnum><issn>1471-2156</issn><eissn>1471-2156</eissn><abstract>Genome-wide association studies have identified variants associated with BMI in populations of European descent. We sought to establish whether genetic variants that are robustly associated with BMI could modulate anthropometric traits and the obesity risk in an Algerian population sample, the ISOR study. We found that each additional risk allele in the GPS was associated with an increment in the mean [95% CI] for BMI of 0.15 [0.06 - 0.24] kg/m2 (p = 0.001). Although the GPS was also associated with higher waist (p = 0.02) and hip (p = 0.02) circumferences, these associations were in fact driven by BMI. The GPS was also associated with an 11% higher risk of obesity (OR [95%CI] = 1.11 [1.05 - 1.18], p = 0.0004). Our data showed that a GPS comprising 29 BMI established loci developed from Europeans seems to be a valid score in a North African population. Our findings contribute to a better understanding of the genetic susceptibility to obesity in Algeria.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25422053</pmid><doi>10.1186/s12863-014-0128-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1471-2156
ispartof BMC genetics, 2014-11, Vol.15 (1), p.128-128, Article 128
issn 1471-2156
1471-2156
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4247883
source PubMed Central
subjects Algeria
Analysis
Body Mass Index
Care and treatment
Disease susceptibility
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Humans
Medical research
Metabolic disorders
Obesity
Obesity - genetics
Polymorphism, Single Nucleotide
Risk factors
Studies
Type 2 diabetes
title Combined effect of established BMI loci on obesity-related traits in an Algerian population sample
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T18%3A51%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20effect%20of%20established%20BMI%20loci%20on%20obesity-related%20traits%20in%20an%20Algerian%20population%20sample&rft.jtitle=BMC%20genetics&rft.au=Badsi,%20Manel%20Nassima&rft.date=2014-11-25&rft.volume=15&rft.issue=1&rft.spage=128&rft.epage=128&rft.pages=128-128&rft.artnum=128&rft.issn=1471-2156&rft.eissn=1471-2156&rft_id=info:doi/10.1186/s12863-014-0128-1&rft_dat=%3Cgale_pubme%3EA539567774%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-b656t-e8a04a18c0c52e517c26d8bdd610635fa1b7fd6254abe60a6ed17ae1575cd44a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1628814131&rft_id=info:pmid/25422053&rft_galeid=A539567774&rfr_iscdi=true