Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: efficacy in preoperative grading

The preoperative grading of gliomas, which is critical for guiding therapeutic strategies, remains unsatisfactory. We aimed to retrospectively assess the efficacy of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in the grading of gliomas. Forty-two newly diagnosed glioma patie...

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Bibliographic Details
Published in:Scientific reports 2014-12, Vol.4 (1), p.7208-7208, Article 7208
Main Authors: Hu, Yu-Chuan, Yan, Lin-Feng, Wu, Lang, Du, Pang, Chen, Bao-Ying, Wang, Liang, Wang, Shu-Mei, Han, Yu, Tian, Qiang, Yu, Ying, Xu, Tian-Yong, Wang, Wen, Cui, Guang-Bin
Format: Article
Language:English
Subjects:
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692/308/575
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Adult
Aged
Brain cancer
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Brain tumors
Diffusion coefficient
Female
Glioma
Glioma - pathology
Glioma - surgery
Humanities and Social Sciences
Humans
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Motion
multidisciplinary
Neoplasm Grading
Preoperative Care - methods
Reproducibility of Results
Science
Sensitivity and Specificity
Variance analysis
Young Adult
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Summary:The preoperative grading of gliomas, which is critical for guiding therapeutic strategies, remains unsatisfactory. We aimed to retrospectively assess the efficacy of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in the grading of gliomas. Forty-two newly diagnosed glioma patients underwent conventional MR imaging, DWI and contrast-enhanced MR imaging. Parameters of apparent diffusion coefficient (ADC), slow diffusion coefficient (D), fast diffusion coefficient (D*) and fraction of fast ADC (f) were generated. They were tested for differences between low- and high-grade gliomas based on one-way ANOVA. Receiver-operating characteristic (ROC) analyses were conducted to determine the optimal thresholds as well as the sensitivity and specificity for grading. ADC, D and f were higher in the low-grade gliomas, whereas D* tended to be lower (all P
ISSN:2045-2322
2045-2322
DOI:10.1038/srep07208