Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center

The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2014-11, Vol.58 (11), p.6949-6952
Main Authors: Locke, Jeffrey B, Zuill, Douglas E, Scharn, Caitlyn R, Deane, Jennifer, Sahm, Daniel F, Goering, Richard V, Jenkins, Stephen G, Shaw, Karen J
Format: Article
Language:English
Subjects:
Acetamides
Acetamides - pharmacology
Anti-Bacterial Agents
Anti-Bacterial Agents - pharmacology
Bacterial Proteins
Bacterial Proteins - genetics
Clindamycin - pharmacology
Diterpenes - pharmacology
Drug Resistance, Multiple, Bacterial - genetics
Gene Transfer Techniques
Humans
Linezolid
Mechanisms of Resistance
Methicillin-Resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - genetics
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial Sensitivity Tests
Molecular Sequence Data
New York
Organophosphates - pharmacology
Oxazoles - pharmacology
Oxazolidinones
Oxazolidinones - pharmacology
Plasmids - genetics
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus
Thiamphenicol - analogs & derivatives
Thiamphenicol - pharmacology
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Summary:The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center in 2011 as part of a routine surveillance program. Each isolate possessed a plasmid containing a pSCFS3-like cfr gene environment. Transformation of the cfr-bearing plasmids into the S. aureus ATCC 29213 background recapitulated the expected Cfr antibiogram, including resistance to linezolid, tiamulin, clindamycin, and florfenicol and susceptibility to tedizolid.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.03380-14