Renal dysfunction in patients with thalassaemia

Summary Little is known about the effects of thalassaemia on the kidney. Characterization of underlying renal function abnormalities in thalassaemia is timely because the newer iron chelator, deferasirox, can be nephrotoxic. We aimed to determine the prevalence and correlates of renal abnormalities...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 2011-04, Vol.153 (1), p.111-117
Main Authors: Quinn, Charles T., Johnson, Valerie L., Kim, Hae‐Young, Trachtenberg, Felicia, Vogiatzi, Maria G., Kwiatkowski, Janet L., Neufeld, Ellis J., Fung, Ellen, Oliveri, Nancy, Kirby, Melanie, Giardina, Patricia J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
albuminuria
Albuminuria - etiology
Anemias. Hemoglobinopathies
beta 2-Microglobulin - urine
Biological and medical sciences
Blood Urea Nitrogen
Calcium - urine
Child
Creatinine - blood
creatinine clearance
Cross-Sectional Studies
Diseases of red blood cells
Female
Hematologic and hematopoietic diseases
Humans
hypercalciuria
Hypercalciuria - etiology
hyperfiltration
kidney
Kidney Diseases - blood
Kidney Diseases - etiology
Kidney Diseases - urine
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
proteinuria
Proteinuria - etiology
thalassaemia
Thalassemia - blood
Thalassemia - complications
Thalassemia - therapy
Thalassemia - urine
transfusion
Transfusion Reaction
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Little is known about the effects of thalassaemia on the kidney. Characterization of underlying renal function abnormalities in thalassaemia is timely because the newer iron chelator, deferasirox, can be nephrotoxic. We aimed to determine the prevalence and correlates of renal abnormalities in thalassaemia patients, treated before deferasirox was widely available, using 24‐h collections of urine. We calculated creatinine clearance and urine calcium‐to‐creatinine ratio and measured urinary β2‐microglobulin, albumin, and protein. We used multivariate modelling to identify clinical, therapeutic, and laboratory predictors of renal dysfunction. One‐third of thalassaemia patients who were not regularly transfused had abnormally high creatinine clearance. Regular transfusions were associated with a decrease in clearance (P = 0·004). Almost one‐third of patients with thalassaemia had hypercalciuria, and regular transfusions were associated with an increase in the frequency and degree of hypercalciuria (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2010.08477.x