Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance

• Published in: World journal of gastroenterology : WJG 2005-02, Vol.11 (8), p.1105-1108
• Main Authors: Xiong, Bin, Sun, Tao-Jiao, Hu, Wei-Dong, Cheng, Fu-Lin, Mao, Min, Zhou, Yun-Feng
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers, Tumor; Colorectal Cancer; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - secondary; Cyclooxygenase 2; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Matrix Metalloproteinase 2 - metabolism; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases - metabolism; Vascular Endothelial Growth Factor A - metabolism; 临床研究; 基因表达; 环氧合酶-2; 肠肿瘤
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v11.i8.1105

AIM: To clarify the clinicopathologic significance of COX-2 expression in human colorectal cancer. METHODS: A total of 128 surgically resected colorectal cancer specimens were immunohistochemically analyzed with the use of anti-COX-2, anti-VEGF and anti-MMP-2 antibodies. The relationship between the cyclooxygenase-2 expression in primary lesions of colorectal cancer and clinicopathologic parameters was evaluated by chi-square test. RESULTS: Among 128 cases of colorectal cancer, 87(67.9%) were positive for cyclooxygenase-2. The expression of cyclooxygenase-2 was significantly correlated with the depth of invasion, stage of disease, and metastasis (lymph node and liver). Patients in T3-T4, stages Ⅲ-Ⅳ and with metastasis had much higher expression of cyclooxygenase-2 than ones in T1-T2, stages Ⅰ-Ⅱ and without metastasis (P