Effects of psychological stress on small intestinal motility and expression of cholecystokinin and vasoactive intestinal polypeptide in plasma and small intestine in mice

To investigate the effects of psychological stress on small intestinal motility and expression of cholecystokinin (CCK) and vasoactive intestinal polypeptide (VIP) in plasma and small intestine, and to explore the relationship between small intestinal motor disorders and gastrointestinal hormones un...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2005-02, Vol.11 (5), p.737-740
Main Authors: Cao, Shu-Guang, Wu, Wan-Chun, Han, Zhen, Wang, Meng-Ya
Format: Article
Language:English
Subjects:
Animals
Brief Reports
Cats
Cholecystokinin - blood
Down-Regulation
Fear - physiology
Gastrointestinal Motility - physiology
Intestine, Small - metabolism
Intestine, Small - physiopathology
Male
Mice
Stress, Psychological - blood
Stress, Psychological - physiopathology
Up-Regulation
Vasoactive Intestinal Peptide - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the effects of psychological stress on small intestinal motility and expression of cholecystokinin (CCK) and vasoactive intestinal polypeptide (VIP) in plasma and small intestine, and to explore the relationship between small intestinal motor disorders and gastrointestinal hormones under psychological stress. Thirty-six mice were randomly divided into psychological stress group and control group. A mouse model with psychological stress was established by housing the mice with a hungry cat in separate layers of a two-layer cage. A semi-solid colored marker (carbon-ink) was used for monitoring small intestinal transit. CCK and VIP levels in plasma and small intestine in mice were measured by radioimmunoassay (RIA). Small intestinal transit was inhibited (52.18+/-19.15% vs 70.19+/-17.79%, P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i5.737