Expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis

AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance.METHODS: A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column,and bhe cord segments C4-6 and...

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Published in:World journal of gastroenterology : WJG 2005-01, Vol.11 (4), p.529-533
Main Authors: Song, Pei-Song, Kong, Kang-Mei, Niu, Chun-Yan, Qi, Wei-Li, Wu, Ling-Fei, Wang, Xin-Jia, Han, Wei, Huang, Keng, Chen, Ze-Feng
Format: Article
Language:English
Subjects:
Animals
Basic Research
c-fos
Cervical Vertebrae
Female
Gastrointestinal Diseases - etiology
Male
Myenteric Plexus - metabolism
Proto-Oncogene Proteins c-fos - metabolism
Pyloric Antrum - innervation
Pyloric Antrum - physiology
Rats
Rats, Sprague-Dawley
Spinal Cord - metabolism
Spinal Osteophytosis - complications
Spinal Osteophytosis - metabolism
Spinal Osteophytosis - physiopathology
基因表达
椎关节强硬
胃肠肌层血管
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container_title World journal of gastroenterology : WJG
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creator Song, Pei-Song
Kong, Kang-Mei
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Wu, Ling-Fei
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Chen, Ze-Feng
description AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance.METHODS: A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column,and bhe cord segments C4-6 and gastric antrum were collected 3, 4 and 5 mo after the operation. Rats with sham operation were used as controls, c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P
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Rats with sham operation were used as controls, c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P&lt;0.05, for the cervical cord; and 11.3±2.3 vs 29.3±4.6,P&lt;0.05, for the gastric antrum). There was no significant difference between rats followed up for 3 mo and those for 4 mo and between rats followed up for 4 mo and those for 5 mo in the model group.CONCLUSION: c-fos expression in gastric myenteric plexus was dramatically associated with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. If this hypothesis is confirmed by furtherstudies, functional gastrointestinal diseases such as functional dyspepsia and irritable bowel syndrome could be explained by neurogastroenterology.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i4.529</identifier><identifier>PMID: 15641140</identifier><language>eng</language><publisher>United States: Department of Joint and Spine,Second Affiliated Hospital, Shantou University Medical College,Shantou 515041, Guangdong Province, China%Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China%Department of Gastroenterology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041,Guangdong Province, China</publisher><subject>Animals ; Basic Research ; c-fos ; Cervical Vertebrae ; Female ; Gastrointestinal Diseases - etiology ; Male ; Myenteric Plexus - metabolism ; Proto-Oncogene Proteins c-fos - metabolism ; Pyloric Antrum - innervation ; Pyloric Antrum - physiology ; Rats ; Rats, Sprague-Dawley ; Spinal Cord - metabolism ; Spinal Osteophytosis - complications ; Spinal Osteophytosis - metabolism ; Spinal Osteophytosis - physiopathology ; 基因表达 ; 椎关节强硬 ; 胃肠肌层血管</subject><ispartof>World journal of gastroenterology : WJG, 2005-01, Vol.11 (4), p.529-533</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2005 Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-421f629631402cdc72d548bd5bd529c64e109150bf0a4b786583bab9b006ea6b3</citedby><cites>FETCH-LOGICAL-c444t-421f629631402cdc72d548bd5bd529c64e109150bf0a4b786583bab9b006ea6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250805/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250805/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15641140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Pei-Song</creatorcontrib><creatorcontrib>Kong, Kang-Mei</creatorcontrib><creatorcontrib>Niu, Chun-Yan</creatorcontrib><creatorcontrib>Qi, Wei-Li</creatorcontrib><creatorcontrib>Wu, Ling-Fei</creatorcontrib><creatorcontrib>Wang, Xin-Jia</creatorcontrib><creatorcontrib>Han, Wei</creatorcontrib><creatorcontrib>Huang, Keng</creatorcontrib><creatorcontrib>Chen, Ze-Feng</creatorcontrib><title>Expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To determine the expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis and its clinical significance.METHODS: A cervical spondylosis model was established in rats by destroying the stability of cervical posterior column,and bhe cord segments C4-6 and gastric antrum were collected 3, 4 and 5 mo after the operation. Rats with sham operation were used as controls, c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P&lt;0.05, for the cervical cord; and 11.3±2.3 vs 29.3±4.6,P&lt;0.05, for the gastric antrum). There was no significant difference between rats followed up for 3 mo and those for 4 mo and between rats followed up for 4 mo and those for 5 mo in the model group.CONCLUSION: c-fos expression in gastric myenteric plexus was dramatically associated with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. If this hypothesis is confirmed by furtherstudies, functional gastrointestinal diseases such as functional dyspepsia and irritable bowel syndrome could be explained by neurogastroenterology.</description><subject>Animals</subject><subject>Basic Research</subject><subject>c-fos</subject><subject>Cervical Vertebrae</subject><subject>Female</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Male</subject><subject>Myenteric Plexus - metabolism</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Pyloric Antrum - innervation</subject><subject>Pyloric Antrum - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Osteophytosis - complications</subject><subject>Spinal Osteophytosis - metabolism</subject><subject>Spinal Osteophytosis - physiopathology</subject><subject>基因表达</subject><subject>椎关节强硬</subject><subject>胃肠肌层血管</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpVUU1r3DAQFaWh2aS99lhEKbnZHcmSPy6FEtI2EMilPQtZlr3aeiVHY-9m_3217NI2IBjBvHnz3jxC3jPIi0rUn_ebId8xljuRS968IivOWZPxWsBrsmIAVdYUvLokV4gbAF4Ukr8hl0yWgjEBK6LvnqdoEV3wNPTUZH1A6jwdNM7RGbo9WD_b428a7fOCVPuO4uS8HqkJsTsORT0j3bt5TY2NO2dSC6fgu8MY0OFbctHrEe27c70mv77d_bz9kT08fr-__fqQGSHEnAnO-pI3ZZFkcdOZindS1G0n0-ONKYVl0DAJbQ9atFVdyrpoddu0AKXVZVtcky8n3mlpt7YzSXfUo5qi2-p4UEE79bLj3VoNYacEl1CDTASfTgR77XvtB7UJS0w-UaUjcwAJAphIsJvznhieFouz2jo0dhy1t2FBVVaFaBirEjA_AU0MiNH2f7UwUMfwjrwqhaecUMljGvjwv4N_8HNaCfDxzLgOfnhySWOrze_ejVYxVtc1r3jxB0UMozI</recordid><startdate>20050128</startdate><enddate>20050128</enddate><creator>Song, Pei-Song</creator><creator>Kong, Kang-Mei</creator><creator>Niu, Chun-Yan</creator><creator>Qi, Wei-Li</creator><creator>Wu, Ling-Fei</creator><creator>Wang, Xin-Jia</creator><creator>Han, Wei</creator><creator>Huang, Keng</creator><creator>Chen, Ze-Feng</creator><general>Department of Joint and Spine,Second Affiliated Hospital, Shantou University Medical College,Shantou 515041, Guangdong Province, China%Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China%Department of Gastroenterology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041,Guangdong Province, China</general><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050128</creationdate><title>Expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis</title><author>Song, Pei-Song ; 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Rats with sham operation were used as controls, c-fos neuronal counter-staining was performed with an immunohistochemistry method. Every third sections from C4-6 segments were drawn. The 10most labeled c-fos-immunoreactive (Fos-IR) neurons were counted, and the average number was used for statistical analysis. The mean of Fos-IR neurons in myenteric plexus was calculated after counting Fos-IR neurons in 25 ganglia from each antral preparation, and expressed as a mean count per myenteric ganglion.RESULTS: There were a few c-fos-positive neurons in the cervical cord and antrum in the control group. There was an increased c-fos expression in model group 3, 4 and 5 mo after operation, whereas there was no significant increase in c-fos expression in the control group at 3, 4 and 5 mo.More importantly, there was a significant difference in c-fos expression between rats followed up for 3 mo and those for 5 mo in the model group (11.20±2.26 vs 27.68±4.36,P&lt;0.05, for the cervical cord; and 11.3±2.3 vs 29.3±4.6,P&lt;0.05, for the gastric antrum). There was no significant difference between rats followed up for 3 mo and those for 4 mo and between rats followed up for 4 mo and those for 5 mo in the model group.CONCLUSION: c-fos expression in gastric myenteric plexus was dramatically associated with that in the spinal cord in rats with cervical spondylosis, suggesting that the gastrointestinal function may be affected by cervical spondylosis. If this hypothesis is confirmed by furtherstudies, functional gastrointestinal diseases such as functional dyspepsia and irritable bowel syndrome could be explained by neurogastroenterology.</abstract><cop>United States</cop><pub>Department of Joint and Spine,Second Affiliated Hospital, Shantou University Medical College,Shantou 515041, Guangdong Province, China%Department of Gastroenterology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China%Department of Gastroenterology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041,Guangdong Province, China</pub><pmid>15641140</pmid><doi>10.3748/wjg.v11.i4.529</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Animals
Basic Research
c-fos
Cervical Vertebrae
Female
Gastrointestinal Diseases - etiology
Male
Myenteric Plexus - metabolism
Proto-Oncogene Proteins c-fos - metabolism
Pyloric Antrum - innervation
Pyloric Antrum - physiology
Rats
Rats, Sprague-Dawley
Spinal Cord - metabolism
Spinal Osteophytosis - complications
Spinal Osteophytosis - metabolism
Spinal Osteophytosis - physiopathology
基因表达
椎关节强硬
胃肠肌层血管
title Expression of c-fos in gastric myenteric plexus and spinal cord of rats with cervical spondylosis
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