Co-opting biology to deliver drugs

ABSTRACT The goal of drug delivery is to improve the safety and therapeutic efficacy of drugs. This review focuses on delivery platforms that are either derived from endogenous pathways, long‐circulating biomolecules and cells or that piggyback onto long‐circulating biomolecules and cells. The first...

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Bibliographic Details
Published in:Biotechnology and bioengineering 2014-09, Vol.111 (9), p.1699-1716
Main Authors: Yousefpour, Parisa, Chilkoti, Ashutosh
Format: Article
Language:English
Subjects:
albumin
Bioengineering
Biology
Biomolecules
Biotechnology
Biotechnology - methods
Blood platelets
Delivery systems
drug delivery
Drug Delivery Systems
Drugs
erythrocyte
Erythrocytes
exosome
Fc fusion
folic acid
lipoprotein
Lipoproteins
macrophage
Pharmaceutical Preparations - administration & dosage
platelet
Platforms
Technology, Pharmaceutical - methods
transferrin
Vitamin B
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Summary:ABSTRACT The goal of drug delivery is to improve the safety and therapeutic efficacy of drugs. This review focuses on delivery platforms that are either derived from endogenous pathways, long‐circulating biomolecules and cells or that piggyback onto long‐circulating biomolecules and cells. The first class of such platforms is protein‐based delivery systems—albumin, transferrin, and fusion to the Fc domain of antibodies—that have a long‐circulation half‐life and are designed to transport different molecules. The second class is lipid‐based delivery systems—lipoproteins and exosomes—that are naturally occurring circulating lipid particles. The third class is cell‐based delivery systems—erythrocytes, macrophages, and platelets—that have evolved, for reasons central to their function, to exhibit a long life‐time in the body. The last class is small molecule‐based delivery systems that include folic acid. This article reviews the biology of these systems, their application in drug delivery, and the promises and limitations of these endogenous systems for drug delivery. Biotechnol. Bioeng. 2014;111: 1699–1716. © 2014 Wiley Periodicals, Inc. The authors present a review of the literature on drug delivery systems that are derived from endogenous biological systems. These drug delivery systems are classified into four categories: protein‐based, lipid‐based, cell‐based, and small molecule‐based drug delivery systems. The biology of these systems, their application in drug delivery, and their promise and limitations as drug delivery vehicles are discussed.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.25307