Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation

Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non‐metal catalysts provides rapid access to a large array of complex nitrogenous structures ideally functionalized for medicinal ap...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2014-07, Vol.356 (10), p.2135-2196
Main Authors: Chakrabarty, Suravi, Choudhary, Shruti, Doshi, Arpit, Liu, Fa-Qiang, Mohan, Rishabh, Ravindra, Manasa P., Shah, Dhruv, Yang, Xun, Fleming, Fraser F.
Format: Article
Language:English
Subjects:
Arrays
Catalysis
Catalysts
Complexation
condensation
coupling
Insertion
isocyanides
isonitriles
Nucleophiles
Synthesis
Transition metals
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Summary:Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with metal and non‐metal catalysts provides rapid access to a large array of complex nitrogenous structures ideally functionalized for medicinal applications. Isonitrile insertion into transition metal complexes has featured in numerous synthetic and mechanistic studies, leading to rapid deployment of isonitriles in numerous catalytic processes, including multicomponent reactions (MCR). Covering the literature from 1990–2014, the present review collates reaction types to highlight reactivity trends and allow catalyst comparison.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201400017