Psoriatic Plaques “Koebnerizing” to Areas of Acanthosis Nigricans in an Obese Female: Clues to a Common Pathway?

Recent evidence suggests that the activation of several growth factor receptors (EGFR, IGFR1, and FGFRs) is a possible cause of acanthosis nigricans, a skin disorder characterized by velvety thin plaques in skin folds and often seen in patients with insulin resistance. The authors report a 14-year-o...

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Bibliographic Details
Published in:The Journal of clinical and aesthetic dermatology 2014-11, Vol.7 (11), p.40-41
Main Authors: Deklotz, Cynthia M. C., Eshagh, Karin, Krakowski, Andrew C.
Format: Article
Language:English
Subjects:
Case Report
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Summary:Recent evidence suggests that the activation of several growth factor receptors (EGFR, IGFR1, and FGFRs) is a possible cause of acanthosis nigricans, a skin disorder characterized by velvety thin plaques in skin folds and often seen in patients with insulin resistance. The authors report a 14-year-old obese (body mass index = 38.5kg/m 2 ) girl with a history of polycystic ovarian syndrome and pre-diabetes who presented with psoriatic plaques in her scalp and, subsequently, in areas mostly confined to where she had characteristic lesions of acanthosis nigricans. The authors propose that this as-of-yet unreported observation may represent a preferential koebnerization phenomenon where the abnormal keratinocyte proliferation in acanthosis nigricans may serve as the epidermal “micro-trauma” necessary to incite the prototypical isomorphic response seen in psoriasis.
ISSN:1941-2789