Spatiotemporal changes in Cx30 and Cx43 expression during neuronal differentiation of P19 EC and NT2/D1 cells

While connexins (Cxs) are thought to be involved in differentiation, their expression and role has yet to be fully elucidated. We investigated the temporal expression of Cx30, Cx36 and Cx43 in two in vitro models of neuronal differentiation: human NT2/D1 and murine P19 cells, and the spatial localis...

Full description

Saved in:
Bibliographic Details
Published in:Cell Biology International Reports (London) 2013-12, Vol.20 (2), p.13-23
Main Authors: Wan, Carthur K., O'Carroll, Simon J., Kim, Sue‐Ling, Green, Colin R., Nicholson, Louise F. B.
Format: Article
Language:English
Subjects:
cell differentiation
in vitro models
intercellular communication
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:While connexins (Cxs) are thought to be involved in differentiation, their expression and role has yet to be fully elucidated. We investigated the temporal expression of Cx30, Cx36 and Cx43 in two in vitro models of neuronal differentiation: human NT2/D1 and murine P19 cells, and the spatial localisation of Cx30 and Cx43 in these models. A temporal Cx43 downregulation was confirmed in both cell lines during RA‐induced neuronal differentiation using RT‐PCR (P 
ISSN:2041-5346
2041-5346
DOI:10.1002/cbi3.10005