Sodium Hydrosulfide Relieves Neuropathic Pain in Chronic Constriction Injured Rats

Aberrant neuronal activity in injured peripheral nerves is believed to be an important factor in the development of neuropathic pain (NPP). Channel protein pCREB of that activity has been shown to mitigate the onset of associated molecular events in the nervous system, and sodium hydrosulfide (NaHS)...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Chen, Jin-zhuan, Lin, Cai-zhu, Luo, Hui-qin, Lin, Jian-qing, Lin, Xian-zhong
Format: Article
Language:English
Subjects:
Alternative medicine
Analgesics
Anesthesiology
Care and treatment
Experimental research
Hydrogen
Hydrogen sulfide
Latency
Medical research
Medicine, Experimental
Molecular chains
Nervous system
Pain
Peripheral nerves
Peripheral neuropathy
Pharmacology
Quality of life
Rats
Rodents
Sciatic nerve
Sodium
Spinal cord
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Summary:Aberrant neuronal activity in injured peripheral nerves is believed to be an important factor in the development of neuropathic pain (NPP). Channel protein pCREB of that activity has been shown to mitigate the onset of associated molecular events in the nervous system, and sodium hydrosulfide (NaHS) could inhibit the expression of pCREB. However, whether NaHS could relieve the pain, it needs further experimental research. Furthermore, the clinical potential that NaHS was used to relieve pain was limited so it would be required. To address these issues, the rats of sciatic nerve chronic constriction injury (CCI) were given intraperitoneal injection of NaHS containing hydrogen sulfide (H2S). The experimental results showed that NaHS inhibited the reduction of paw withdrawal thermal latency (PWTL), mechanical withdrawal threshold (MWT), and the level of pCREB in CCI rats in a dose-dependent manner and they were greatly decreased in NaHSM group (P < 0.05). NaHS alleviates chronic neuropathic pain by inhibiting expression of pCREB in the spinal cord of Sprague-Dawley rats.
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/514898