In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus

Canine distemper virus (CDV) is a morbillivirus related to measles virus that infects dogs and other carnivores. CDV has a significant global impact on animal health; however, there is no current antiviral treatment for CDV infection. In recent years, it has been demonstrated that sulfated polysacch...

Full description

Saved in:
Bibliographic Details
Published in:Virusdisease 2014-12, Vol.25 (4), p.474-480
Main Authors: Trejo-Avila, Laura M., Morales-Martínez, Maria Elena, Ricque-Marie, Denis, Cruz-Suarez, L. Elizabeth, Zapata-Benavides, Pablo, Morán-Santibañez, Karla, Rodríguez-Padilla, Cristina
Format: Article
Language:English
Subjects:
Adsorption
Algae
Antiviral activity
Biochemistry
Biomedical and Life Sciences
Canine distemper
Carnivores
Cell Biology
Cell fusion
Cell walls
Cladosiphon okamuranus
Cytotoxicity
Dengue fever
Drug dosages
Fucoidan
Infections
Life Sciences
Microbiology
Original
Original Article
Polysaccharides
Protein Structure
Sulfuric acid
Vero cells
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Canine distemper virus (CDV) is a morbillivirus related to measles virus that infects dogs and other carnivores. CDV has a significant global impact on animal health; however, there is no current antiviral treatment for CDV infection. In recent years, it has been demonstrated that sulfated polysaccharides exhibit antiviral properties both in vivo and in vitro, despite their low cytotoxicity to host cells. Fucoidan is a sulfated polysaccharide found in the cell wall matrix of brown algae. In this study, we evaluated in vitro anti-CDV activity of fucoidan, which was derived from Cladosiphon okamuranus . Fucoidan actively inhibited CDV replication in Vero cells at a 50 % inhibitory concentration (IC 50 ) of 0.1 µg/ml. The derived selectivity index (SI 50 ) was >20,000. This polysaccharide likely inhibits viral infection by interference in the early steps and by inhibiting CDV-mediated cell fusion. Fucoidan may be useful in development of pharmacological strategies to treat and control CDV infection.
ISSN:2347-3584
2347-3517
DOI:10.1007/s13337-014-0228-6